{"id":40,"date":"2006-11-13T12:59:50","date_gmt":"2006-11-13T11:59:50","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2006\/11\/13\/jama-8-november-2006\/"},"modified":"2006-11-13T12:59:50","modified_gmt":"2006-11-13T11:59:50","slug":"jama-8-november-2006","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2006\/11\/13\/jama-8-november-2006\/","title":{"rendered":"JAMA 8 November 2006"},"content":{"rendered":"<p>As many people get older, they become fatter and their blood pressure rises. Some become diabetic. To maintain cardiac output, heart myocytes hypertrophy and stay hypertrophied over long periods, causing some of them to die early (apoptosis), and giving rise in the long term to a stiff left ventricle. <!--more-->At the same time, the large capacitance arteries lose a lot of their elasticity, causing them to reflect an increasing pressure wave back at the heart during systole. During diastole, the left ventricle and the coronary arteries fill less effectively, and eventually a <a href=\"http:\/\/jama.ama-assn.org\/cgi\/content\/full\/296\/18\/2209\">syndrome of heart failure with preserved ejection fraction<\/a> results. Because our classic model of \u201cheart failure<\/p>\n","protected":false},"excerpt":{"rendered":"<p>As many people get older, they become fatter and their blood pressure rises. Some become diabetic. To maintain cardiac output, heart myocytes hypertrophy and stay hypertrophied over long periods, causing [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2006\/11\/13\/jama-8-november-2006\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111],"tags":[],"class_list":["post-40","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>JAMA 8 November 2006 - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2006\/11\/13\/jama-8-november-2006\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JAMA 8 November 2006 - The BMJ\" \/>\n<meta property=\"og:description\" content=\"As many people get older, they become fatter and their blood pressure rises. 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