{"id":37544,"date":"2016-10-11T14:23:09","date_gmt":"2016-10-11T13:23:09","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=37544"},"modified":"2017-08-08T13:20:28","modified_gmt":"2017-08-08T12:20:28","slug":"avril-danczak-when-is-a-disease-not-a-disease","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2016\/10\/11\/avril-danczak-when-is-a-disease-not-a-disease\/","title":{"rendered":"Avril Danczak: When is a disease not a disease?"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-37023\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2016\/07\/avril_danczak.jpg\" alt=\"avril_danczak\" width=\"200\" height=\"250\" \/>Most GPs will recognise the dispiriting conversation that can happen when a patient discovers that they have Chronic Kidney Disease Stage 3 (CKD). \u201cA disease? Where did I catch it from? Will the grandkids get it? What is the treatment?\u201d<\/p>\n<p>Patients know what a disease is; a condition that you acquire or catch, that makes you feel unwell, gets in the way of normal life. With luck, modern medicine will have some kind of cure. If not, diseases must be endured, maybe modified, maybe even seen as a signal for wills to be made, bucket lists ticked off, last words uttered.<!--more--><\/p>\n<p>Well, we doctors know that CKD3 it is not that kind of disease, actually. A patient\u2019s eGFR has slipped a few points below an arbitrary threshold, the treatment they are on already is fine, the shift of stage mostly is just due to age catching up a little more. Moreover, the threshold in question can change again when an \u201cexpert group\u201d of some kinds moves the goalposts. Those who had normal blood sugars or cholesterols a few years ago are now seen as \u201cabnormal\u201d. \u00a0Almost all these changes move in the direction of making so called \u201cdiagnoses\u201d at ever reducing thresholds.<\/p>\n<p>And then there is \u201crisk.\u201d<\/p>\n<p>\u201cRisk\u201d is a number, itself often derived from an amalgam of other numbers, like \u201ccardiovascular system (CVS) risk.\u201d Like the bonds in the Sub-Prime crisis that caused the 2008 economic crash, these derivatives look set to bankrupt health services all over the place. There is an implicit view that a given CVS risk is like a disease state\u2026something objective, separate from the patient\u2019s own experience (\u201cillness\u201d) and that treatment results in \u201clives saved\u201d from heart disease or a stroke. Those in favour of mass treatment cite the benefits, those in favour of shared decision making emphasise the importance of individuals\u2026their choices, their experiences of the drug, what they as individuals stand to gain.<\/p>\n<p>The key point is that CVS risk thresholds are not diseases to be \u201ctreated\u201d with statins. Those \u201cat risk\u201d are by definition, disease free. Instead of being offered \u201ctreatment,\u201d perhaps we should invite patients to enter the \u201cstatin lottery.\u201d A few stand to get a big gain from a prevented heart attack or stroke that could shorten life and certainly affect its quality. However, it really is a lottery.<\/p>\n<p>How much reduction in risk could we expect with treatment? <a href=\"http:\/\/www.parksmed.co.uk\/wp-content\/uploads\/2013\/09\/Statins_Patient-decision-aids.pdf\">The NPC decision aid<\/a>\u00a0indicates that at\u00a010% risk as few as 3 out of 100 patients who take statins for 10 years will get this benefit. Even those who do get this benefit will never know whether it was just good luck or whether it was the statin; \u00a07\/100 patients who take statins at a 10% risk will still go to get heart attacks and strokes, and will have had 10 years of pills for little benefit.<\/p>\n<p>The gains in the statin lottery come at a cost to others; most patients will have to take the risk of not getting any benefit and possibly of suffering harm; from side effects, as well as considerable inconvenience, costs to the health service and opportunities to spend money on something else foregone.<\/p>\n<p>We could explain this like taxes and the NHS\u2026we all pay up and hope we will be the lucky ones who don\u2019t have to use it. But let us be honest with patients about what we are asking; we would like them all to join in (and suffer any side effects\/inconvenience or cost) so that a very few can benefit. We simply do not know whether they themselves will benefit. Looked at like this patients may make a different decision to epidemiologists.<\/p>\n<p>So when is a disease not a disease? \u00a0When it is just a \u201crisk factor.\u201d<\/p>\n<p><em><strong>Avril Danczak<\/strong> is a GP in Manchester and a Primary Care Medical Educator training General Practitioners on the Central and South Manchester Specialty Training Programme for General Practice. She is currently working on a patient safety project about diagnosis in General Practice.<\/em><\/p>\n<p><em><strong>Competing interests:<\/strong> I have co authored a book called Mapping Uncertainty in Medicine: what do you do when you don&#8217;t know what to do? by Avril Danczak Alison Lea and Geraldine Murphy. RCGP books.<\/em><\/p>\n<p><strong>Correction:<\/strong> This piece was amended on 8 August 2017 to make it clear that CVS stands for cardiovascular system.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Most GPs will recognise the dispiriting conversation that can happen when a patient discovers that they have Chronic Kidney Disease Stage 3 (CKD). \u201cA disease? Where did I catch it [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2016\/10\/11\/avril-danczak-when-is-a-disease-not-a-disease\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5756],"tags":[],"class_list":["post-37544","post","type-post","status-publish","format-standard","hentry","category-too-much-medicine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Avril Danczak: When is a disease not a disease? - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2016\/10\/11\/avril-danczak-when-is-a-disease-not-a-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avril Danczak: When is a disease not a disease? - The BMJ\" \/>\n<meta property=\"og:description\" content=\"Most GPs will recognise the dispiriting conversation that can happen when a patient discovers that they have Chronic Kidney Disease Stage 3 (CKD). \u201cA disease? 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