{"id":36922,"date":"2016-06-21T11:47:24","date_gmt":"2016-06-21T10:47:24","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=36922"},"modified":"2016-06-21T11:47:41","modified_gmt":"2016-06-21T10:47:41","slug":"kamal-r-mahtani-beware-evidence-spin-an-important-source-of-bias-in-the-reporting-of-clinical-research","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2016\/06\/21\/kamal-r-mahtani-beware-evidence-spin-an-important-source-of-bias-in-the-reporting-of-clinical-research\/","title":{"rendered":"Kamal R Mahtani: Beware evidence \u201cspin\u201d: an important source of bias in the reporting of clinical research"},"content":{"rendered":"

\"KamalDoes the name <\/span>Malcolm Tucker<\/span><\/a> ring a bell? The Malcolm Tucker I am referring to is the fictional character from the BBC political satire <\/span>The Thick of it<\/span><\/i><\/a>. Tucker (played by <\/span>Peter Capaldi<\/span><\/a>) was a government director of communications, skilled in propaganda, more specifically in the art of \u201c<\/span>spinning<\/span><\/a>\u201d unfavorable information into a more complimentary, approving (and sometimes even glowing) public facing message. Whether the show accurately reflects <\/span>real life<\/span><\/a> governmental politics, or whether real life politicians “<\/span>copy<\/a>“<\/span>\u00a0the show, remains a topic of discussion. Either way, \u201cspin\u201d in the political arena feels like something we are increasingly getting used to, almost expect.<\/span><\/p>\n

\u201cSpin\u201d in reports of clinical research <\/b><\/p>\n

For many researchers, the number of publications, and the impact of those publications, is the usual currency for measuring professional worth. Furthermore, we are increasingly seeing researchers discuss their work in public through mainstream and social media, as more of these opportunities arise. With this in mind it probably won\u2019t come as such a shock to imagine that researchers might be tempted to report their results in a more favorable (again, even glowing) way than they deserve i.e. to add some \u201cspin.<\/span>\u201d<\/b><\/p>\n

According to the <\/span>EQUATOR network<\/span><\/a>, such practice constitutes misleading reporting, and specifically the misinterpretation of study findings (e.g. presenting a study in a more positive way than the actual results reflect, or the presence of discrepancies between the abstract and the full text).<\/span><\/p>\n

\u201cResearchers have a duty to make publicly available the results of their research on human subjects and are accountable for the completeness and accuracy of their reports.\u201d (<\/span><\/i>WMA Declaration of Helsinki<\/a>)<\/span><\/i><\/i><\/p>\n

So how common is \u201cspin<\/span>\u201d<\/b> in clinical research? An <\/span>analysis<\/span><\/a> of 72 randomised controlled trials that reported primary outcomes with statistically <\/span>non-significant<\/span><\/i> results, found that more than 40% of the trials had some form of \u201cspin<\/span>,”<\/b>\u00a0defined by the authors as the \u201cuse of specific reporting strategies, from whatever motive, to highlight that the experimental treatment is beneficial, despite a statistically nonsignificant difference for the primary outcome, or to distract the reader from statistically non-significant results.\u201d The analysis identified a <\/span>number of strategies<\/span><\/a> for \u201cspin,<\/span>\u201d<\/b>\u00a0with some of the most common being to focus reporting on statistically significant results for other analyses, i.e. not the primary outcomes; or to focus on another study objective and distract the reader from a statistically nonsignificant result. \u00a0Another <\/span>analysis<\/span><\/a>, this time involving 107 randomised controlled trials in oncology, similarly found that nearly half of the trials demonstrated some form of \u201cspin\u201d in either the abstract or the main text.<\/span><\/p>\n

You might think that <\/span>systematic reviews<\/span><\/a> of primary research should address some of these problems. By seeking the totality of available evidence, interpreting the impact of bias, and then synthesising the evidence into a useable form, they can be powerful tools for informing clinical decisions. But not all systematic reviews are equal. Non-Cochrane systematic reviews have been shown to be <\/span>twice as likely<\/span><\/a> to have positive conclusion statements than Cochrane reviews. Furthermore, non-Cochrane reviews, when matched to an equivalent Cochrane review on the same topic, were <\/span>more likely<\/span><\/a> to report larger effect sizes with lower precision than the equivalent Cochrane review. In both cases, these findings may well reflect <\/span>the extent to which methodological complexity is ignored or sidestepped in poorer quality reviews. <\/span>\u00a0<\/span><\/p>\n

So not all systematic reviews are equal, and neither are they exempt from \u201cspin.<\/span>\u201d<\/b>\u00a0A <\/span>review<\/span><\/a> of the presence of \u201cspin\u201d (defined as the consistency of reporting between the abstract\/conclusions and the empirical data) in reviews of psychological therapies found that \u201cspin\u201d was present in 27 of the 95 included reviews (28%). In fact, a recent study identified <\/span>39 different types of \u201cspin<\/span><\/a>\u201d<\/span> that may be found in a systematic review. Thirteen of those were specific to reports of systematic reviews and meta-analysis. <\/span>When a sample of Cochrane systematic review editors and methodologists were asked to rank the most severe types of \u201cspin<\/span>\u201d <\/b>found in the abstracts of a review, their top three were (1) recommendations for clinical practice not supported by findings in the conclusion, (2) a misleading title, and (3) selective reporting.<\/span><\/p>\n

Impacts of \u201cspin\u201d from clinical research<\/b><\/p>\n

\u201cSpin\u201d may influence the interpretation of information by clinicians. A randomised controlled <\/span>trial<\/span><\/a> allocated 150 clinicians to assess a sample of cancer related abstracts with \u201cspin\u201d and another 150 clinicians to assess the same abstract with the \u201cspin\u201d removed. Although the absolute effect size was small, the study found that the presence of \u201cspin\u201d was statistically more likely to result in the clinicians reporting that the treatment was beneficial. Interestingly the study also found that \u201cspin\u201d resulted in clinicians rating the study as being <\/span>less<\/span><\/i> rigorous and they were more likely to want to review the full text-article.<\/span><\/p>\n

Dissemination<\/span><\/a> of research findings to the public e.g. through mainstream media, can also be a source of added \u201cspin.\u201d An <\/span>analysis<\/span><\/a> of 498 scientific press releases from the <\/span>EurekAlert!<\/span><\/a> Database identified 70 that referred to two-arm, parallel-group RCTs. \u201cSpin,\u201d which included a tendency to put more emphasis on the beneficial effects of a treatment, was identified in 33 (47%) of the press releases. Furthermore, the authors of the analysis found that the main factor associated with \u201cspin\u201d in a press releases was the presence of \u201cspin\u201d in the abstract conclusion.<\/span><\/p>\n

So what motivates \u201cspin\u201d? <\/b><\/p>\n

This is a complex area, to which more relevant research might add clarity. A desire to demonstrate impact has already been suggested as one driver. Other <\/span>proposed <\/span><\/a>mechanisms include (1) ignorance of scientific standards, (2) young researchers’ imitation of previous practice, (3) unconscious prejudice, or (4) willful intent to influence readers.<\/span><\/p>\n

Conflicts of interest (COI) will almost certainly have some bearing on the presence of \u201cspin.\u201d \u00a0As an example, an <\/span>overview<\/span><\/a> of systematic reviews examined whether financially related conflicts of interest influenced the overall conclusions from systematic reviews that examined the relationship between the consumption of sugar-sweetened beverages (SSBs) and weight gain or obesity. Of the included studies, 5\/6 systematic reviews that disclosed some form of financial conflict of interest with the food industry, reported no association between SSB consumption and weight gain. In contrast, 10\/12 reviews, which reported no potential conflicts of interest, found <\/span>that SSB consumption could be a potential risk factor for weight gain.<\/span><\/p>\n

However, while a great deal of discussion focuses on financial COI, the \u201c<\/span>blind spot<\/span><\/a>\u201d may be <\/span>non-financial<\/span><\/i> conflicts of interest (NFCOI), which could have an even greater bearing on the presence of \u201cspin.<\/span>\u201d\u00a0<\/b>For systematic reviews, these types of conflicts have been <\/span>defined<\/span><\/a> as \u201ca set of circumstances that creates a risk that the primary interest\u2014the quality and integrity of the systematic review\u2014will be unduly influenced by a secondary or competing interest that is not mainly financial.\u201d Examples of NFCOI <\/span>include<\/span><\/a> strongly held personal beliefs (e.g. leading to a possible \u201c<\/span>allegiance bias<\/span><\/a>\u201d), personal relationships, a desire for career advancement, or (increasingly possible now) a greater media profile. All of these have the potential to affect professional judgment and thus generate a message that does not convey a fair <\/span>test of treatment<\/span><\/a>.<\/span><\/p>\n

Unfortunately a significant proportion of clinical research is already littered with various types of <\/span>bias<\/span><\/a>, which we know can influence the <\/span>treatments<\/span><\/a> we provide our patients as well as <\/span>waste<\/span><\/a> valuable resources. The added bias of \u201cspin,<\/span>\u201d<\/b>\u00a0whether <\/span>motivated<\/span><\/a> by financial, personal, or intellectual conflicts of interest, or even plain ignorance, further obfuscates the problem.<\/span><\/p>\n

Beware evidence \u201c<\/span>spin.<\/b>\u201d<\/span><\/p>\n

Kamal R Mahtani<\/i><\/b>\u00a0is a GP, NIHR clinical lecturer and deputy director of the\u00a0<\/span><\/i>Centre for Evidence Based Medicine<\/span><\/i><\/a>, Nuffield Department of Primary Care Health Sciences, University of Oxford. He is also a member of the\u00a0<\/span><\/i>Evidence Live 2016<\/span><\/i><\/a>\u00a0steering committee which brings together leading speakers in evidence-based medicine from all over the world, from the fields of research, clinical practice and commissioning. \u00a0<\/span><\/i><\/p>\n

You can follow him on Twitter at\u00a0<\/span>@krmahtani<\/span><\/a><\/p>\n

Competing interests:<\/i><\/b>\u00a0I have read and understood BMJ policy on competing interests. I declare no competing interests relevant to this article.<\/span><\/i><\/p>\n

Disclaimer:<\/i><\/b>\u00a0The views expressed are those of the author and not necessarily of any of the institutions or organisations mentioned in the article.<\/span><\/i><\/p>\n

Acknowledgements:<\/i><\/b>\u00a0Thanks to Jeff Aronson, Meena Mahtani and Annette Pl\u00fcddemann for helpful comments.<\/span><\/i><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Does the name Malcolm Tucker ring a bell? The Malcolm Tucker I am referring to is the fictional character from the BBC political satire The Thick of it. Tucker (played […]<\/p>\n

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