{"id":35580,"date":"2015-10-30T12:16:14","date_gmt":"2015-10-30T11:16:14","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=35580"},"modified":"2015-11-02T12:46:12","modified_gmt":"2015-11-02T11:46:12","slug":"jeffrey-aronson-when-i-use-a-word-a-twist-on-the-nobel-prize","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2015\/10\/30\/jeffrey-aronson-when-i-use-a-word-a-twist-on-the-nobel-prize\/","title":{"rendered":"Jeffrey Aronson: When I use a word . . . A twist on the Nobel Prize"},"content":{"rendered":"

\"jeffrey_aronson\"<\/a>As I was saying, bile and gall<\/a>, from the same linguistic roots, mean the same things. At least, \u201cbile\u201d means a secretion of the liver, anger, ill temper, and bitterness, and so does \u201cgall\u201d, although there are meanings of \u201cgall\u201d (impudence, for example) that do not belong to \u201cbile\u201d. The King James\u2019 Bible, does not mention \u201cbile\u201d, but it does mention \u201cgall\u201d, 13\u00a0times, in three different meanings: the hepatic secretion, metaphorical bitterness, and in describing a poisonous bitter herb as \u201ca root that beareth gall and wormwood\u201d.<\/p>\n

Wormwood supposedly sprang up in the trail of the serpent (or worm) as it left paradise, and Culpeper<\/a> recommended it for worms, among many other things, as did Mrs Grieve<\/a>. But \u201cwormwood\u201d comes from a mishearing or misspelling of \u201cwermod\u201d, listed in the Corpus Glossary of 725<\/a> as a gloss of the Latin word absinthium. Vermouth has absinth<\/a> in it. Wormwood may have something to do with worms, for sure, but not specifically wood.<\/p>\n

The many forms of the Indo-European root UER included ones that mean to twist or turn. Rotate a twig, Boy Scout fashion, and you ignite it, so UER came to mean the twig itself and by extension twig like objects, such as a rod (Greek \u1fe5\u03b1\u03b2\u03b4\u03bf\u03c2) or a club (Greek \u1fe5\u03cc\u03c0\u03b1\u03bb\u03bf\u03bd). In Latin virga was a twig or young shoot and virgo a virgin. Verbera were reverberating rods or whips. Ritual rods were made from verbenae, twigs of laurel, olive, myrtle, or cypress. A verger carried a rod as a sign of his office; so \u201cverge\u201d means the limits of one\u2019s authority.<\/p>\n

Latin vertere, to turn, gives us vortex, vertigo, anniversary, controversy, inverse, reverse, extravert, introvert, converge, diverge, indeed any word ending in \u2013verse\/vert\/verge. Versatile people can turn their hands to anything. Verse turns from line to line, whereas prose is straightforward (Latin prorsus, perversely shortened from pro+versus).<\/p>\n

Introrse, extrorse, sinistrorse, and dextrorse truncatedly turn in, out, left, and right. The recto is a right hand page of a book, such as the title page; the verso is the page on the other side, with details about the publisher, date of publication, ISBN, and so on. Tinea versicolor is a multicoloured rash. Your trunk twists about its vertebrae. The twisting worm is vermis in Latin. Vermicelli are worm shaped pieces of pasta, and the vermiform appendix is worm like.<\/p>\n

Teutonic twists on this give worry (originally meaning to strangle), wrangle, wreath, wrench, wrestle, wriggle, wring, wrinkle, wrist (a twisting joint), writhe, and wrong (i.e. twisted). Inward, outward, upward, downward, forward, and backward show where to turn.<\/p>\n

So what was the biblical root bearing gall and wormwood? It doesn\u2019t have to be a specific plant, since the phrase was metaphorical, but what we call common wormwood is Artemisia absinthium<\/em>. Other varieties have other names: A. gallica <\/em>is French wormwood, A. pontica<\/em> Roman wormwood, A. maritima<\/em> sea wormwood, A. arborescens<\/em> tree wormwood. Artemisia<\/em> is named after the Greek goddess Artemis, perhaps because it was used for obstetric or gynaecological purposes, with which she was associated, having supposedly helped her mother deliver her twin brother Apollo immediately after she herself was born, or because she gave it to Chiron the centaur. The origin of Artemis’s name is not known. It may not even have been Greek. But one of several possibilities is that it came from the word for a butcher, \u1f04\u03c1\u03c4\u1fb0\u03bc\u03bf\u03c2; Artemis, being a huntress, would have butchered the animals she killed. A similar word meaning safe or sound,\u00a0\u1f00\u03c1\u03c4\u03b5\u03bc\u03ae\u03c2, may reflect her virginity.<\/p>\n

This year\u2019s Nobel Prize in Physiology or Medicine<\/a> was awarded for two pharmacological discoveries, one of which was the rediscovery, by the Chinese pharmacologist Tu Youyou, of Artemisia annua<\/em>, known in Chinese as qinghao<\/a>, as a treatment for malaria. Qinghao was used to treat fevers by the 4th<\/sup> century physician Ge Hong (picture). He soaked the leaves of the plant in cold water and then twisted them, wringing out the sap. Heat would have destroyed the labile active ingredients, qinghaosu, cyclic endoperoxides, and the wringing out process is supposed to have created an emulsion in which they were stable. Coincidentally (or not?), the other awards this year were for treatments for worms. So we see the importance of twisting.<\/p>\n

Images:<\/strong> Ge Hong (284-363) and an extract from \u201cEmergency Prescriptions Kept up One\u2019s Sleeve\u201d in Chapter 3, Section 16, \u201cPrescriptions for treating intermittent hot and cold conditions and all kinds of intermittent fevers\u201d: \u201cAnother recipe: take one bunch of qinghao, add two sheng of water, soak it, wring it out, take all of the juice, and ingest it.\u201d<\/p>\n

\"aronson_a<\/a>\"aronson_a<\/a><\/p>\n

Jeffrey Aronson<\/strong> is a clinical pharmacologist, working in the Centre for Evidence Based Medicine in Oxford’s Nuffield Department of Primary Care Health Sciences. He is also president emeritus of the British Pharmacological Society.<\/em><\/p>\n

Competing interests:\u00a0None declared.<\/p>\n","protected":false},"excerpt":{"rendered":"

As I was saying, bile and gall, from the same linguistic roots, mean the same things. At least, \u201cbile\u201d means a secretion of the liver, anger, ill temper, and bitterness, […]<\/p>\n

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