{"id":33991,"date":"2015-04-24T10:32:54","date_gmt":"2015-04-24T09:32:54","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=33991"},"modified":"2015-04-24T10:32:54","modified_gmt":"2015-04-24T09:32:54","slug":"the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2015\/04\/24\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\/","title":{"rendered":"The BMJ Today:\u00a0Cancer drugs, BMJ awards, and challenges for the NHS"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/fda.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-33994\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/fda-300x194.jpg\" alt=\"fda\" width=\"192\" height=\"124\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/fda-300x194.jpg 300w, https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/fda.jpg 540w\" sizes=\"auto, (max-width: 192px) 100vw, 192px\" \/><\/a>\u2022 <a href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2068\">Donald Light and Joel Lexchin write about the easy ride cancer drugs get<\/a> in the approval process. They point to three weaknesses: trials on cancer drugs are more often unblinded and non-randomised; these drugs are more often approved through accelerated pathways; and, finally, they often use surrogate endpoints. The result is very expensive medicines with little added value: \u201cThe 71 drugs approved by the FDA from 2002 to 2014 for solid tumours have resulted in median gains in progression-free and overall survival of only 2.5 and 2.1 months, respectively.\u201d<!--more--><\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/bma_awards.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright  wp-image-33995\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/bma_awards-300x194.jpg\" alt=\"bma_awards\" width=\"241\" height=\"156\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/bma_awards-300x194.jpg 300w, https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/bma_awards.jpg 540w\" sizes=\"auto, (max-width: 241px) 100vw, 241px\" \/><\/a>\u2022 The yearly BMJ Awards are coming up, and <a href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2125?etoc\">Nigel Hawkes discusses the five studies that have been shortlisted for UK Research paper of the year<\/a>. They are a varied bunch, but all fascinating. There are even three \u201cnegative\u201d studies among them: one meta-analysis on the variability of results in stem cell trials, showing that the more discrepancies a paper contained, the more positive its results. The other meta-analysis showed that one cannot use HbA1c to predict cardiovascular risk. The other study with a \u201cnull\u201d finding was a large trial showing that GPs can safely delay antibiotic prescriptions to patients with respiratory tract infections.<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/money_loss.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-33996\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/money_loss-300x173.jpg\" alt=\"money_loss\" width=\"206\" height=\"119\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/money_loss-300x173.jpg 300w, https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/money_loss.jpg 436w\" sizes=\"auto, (max-width: 206px) 100vw, 206px\" \/><\/a>\u2022 Speaking of negative results, the NHS seems to be receiving their share of it too. <a href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2180?etoc=\">Gareth Iacobucci reports that hospitals and other NHS providers in England are set to post a record deficit of more than \u00a3800m this year<\/a>. Apart from this financial problem, the report identified staff morale as a top concern. The future does not look any brighter either, as the majority of directors \u201cpredicted a \u2018high\u2019 or \u2018very high\u2019 risk of failing to achieve \u00a322bn in productivity gains over the next five years as outlined by NHS England\u2019s <em>Five Year Forward View<\/em>.\u201d<\/p>\n<p>\u2022 <a href=\"http:\/\/www.bmj.com\/content\/350\/bmj.h2041?etoc=\">John Fabre presents his way forward in the latest\u00a0\u201cIf I ruled the NHS\u201d column<\/a>. He clearly wants more doctors and nurses in the driving seat: more NHS England board members with a medical or nursing background, and one clinical chief executive for each hospital. GPs should be given more autonomy and clinical commissioning should be abolished.<\/p>\n<p><em><strong>Wim Weber<\/strong>\u00a0is European research editor for <\/em>The BMJ<em>.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2022 Donald Light and Joel Lexchin write about the easy ride cancer drugs get in the approval process. They point to three weaknesses: trials on cancer drugs are more often [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2015\/04\/24\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5750],"tags":[],"class_list":["post-33991","post","type-post","status-publish","format-standard","hentry","category-the-bmj-today"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The BMJ Today:\u00a0Cancer drugs, BMJ awards, and challenges for the NHS - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2015\/04\/24\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The BMJ Today:\u00a0Cancer drugs, BMJ awards, and challenges for the NHS - The BMJ\" \/>\n<meta property=\"og:description\" content=\"\u2022 Donald Light and Joel Lexchin write about the easy ride cancer drugs get in the approval process. They point to three weaknesses: trials on cancer drugs are more often [...]More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/bmj\/2015\/04\/24\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\/\" \/>\n<meta property=\"og:site_name\" content=\"The BMJ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/bmjdotcom\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-24T09:32:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/bmj\/files\/2015\/04\/fda-300x194.jpg\" \/>\n<meta name=\"author\" content=\"BMJ\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:site\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"BMJ\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/\"},\"author\":{\"name\":\"BMJ\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/person\\\/ba3da426ed20e8f1d933ca367d8216fe\"},\"headline\":\"The BMJ Today:\u00a0Cancer drugs, BMJ awards, and challenges for the NHS\",\"datePublished\":\"2015-04-24T09:32:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/\"},\"wordCount\":362,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/files\\\/2015\\\/04\\\/fda-300x194.jpg\",\"articleSection\":[\"The BMJ today\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/04\\\/24\\\/the-bmj-today-cancer-drugs-bmj-awards-and-challenges-for-the-nhs\\\/\",\"name\":\"The BMJ Today:\u00a0Cancer drugs, BMJ awards, and challenges for the NHS - 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