{"id":33098,"date":"2015-01-05T16:46:13","date_gmt":"2015-01-05T15:46:13","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=33098"},"modified":"2015-01-05T16:53:06","modified_gmt":"2015-01-05T15:53:06","slug":"pills-from-the-world","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/","title":{"rendered":"Luca De Fiore and Tom Jefferson: Pills from the world"},"content":{"rendered":"<p>European regulatory agencies frequently inform doctors and pharmacists about their activities, paying particular attention to pharmacovigilance. The Italian Medicines Agency (AIFA) started a new information feed on 3 April 2012: &#8220;<a href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/pillole-dal-mondo-0\">Pills from the world<\/a>.&#8221; Every morning a news item is posted online, but analysis of some of the posted items is thought provoking.<\/p>\n<p>AIFA declares that the news items are abstracted from research papers &#8220;published in selected scientific journals\u201d\u2014a very onerous task, <a href=\"http:\/\/www.plosmedicine.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pmed.1000326\">given the number of studies published daily<\/a>. AIFA does not clarify the criteria for the selection of the sources, and the choice seems generally random.<!--more--><\/p>\n<p>On 10 November 2014, <a href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/lercanidipina-e-nifedipina-gits-non-intercambiabili-nel-trattamento-dell%E2%80%99ipertensione-prim-0\">a news item that<\/a> focused on two antihypertensive agents was published. It was abstracted from a journal published by the Baishideng Publishing Group, a &#8220;predatory publisher&#8221; <a href=\"http:\/\/scholarlyoa.com\/2012\/12\/06\/bealls-list-of-predatory-publishers-2013\/\">as reported by the list published annually<\/a> by the documentalist Jeffrey Beall.<\/p>\n<p>AIFA also states that &#8220;the goal [of &#8220;Pills from the world&#8221;] is to provide . . . a complete and independent information feed.&#8221; Strangely, <a href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/pharmacoepidemiology-drug-safety-uno-studio-su-sicurezza-e-tollerabilit%C3%A0-di-oseltamivir-nei-\">on 19 November 2014<\/a> a news item was devoted to a study about the safety and tolerability of oseltamivir in infants and children. The item did not report that the authors of the study are employees of Roche, Genentech, and Quintiles. William Blumentals (one of the authors) is among <a href=\"http:\/\/www.bmj.com\/content\/348\/bmj.g2371\">the most frequently cited authors in the investigation<\/a> about the &#8220;Tamiflu saga.&#8221;<\/p>\n<p>The overwhelming supply of studies\u00a0should enable a careful selection\u00a0of the sources of information on\u00a0&#8220;Pills from the world.&#8221; &#8220;Less is more&#8221; also applies in this area if we consider that, of the 60 000 articles published each year in the 140 most cited journals, <a href=\"http:\/\/ebm.bmj.com\/content\/13\/1\/3.extract\">only 5% survive an evaluation of the quality of the research methods used by the authors<\/a>.<\/p>\n<p>When informing doctors and pharmacists about the use of medicines, public institutions such as AIFA should wisely select the primary literature, keeping in mind that <a href=\"http:\/\/www.plosone.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pone.0000005\">the most valuable papers are concentrated in a few journals<\/a>. In all cases, sources should be critically evaluated.<\/p>\n<p>A closer monitoring of the activities of the national health institutions\u00a0by the scientific and academic community is needed. This is the aim of the new project \u201c<a href=\"http:\/\/politichedelfarmaco.it\/\">Politiche del Farmaco<\/a>\u201d (Drug Policies), which was started by the Italian members associated with the International Society of Drug Bulletins.<\/p>\n<p><em><strong>Luca De Fiore<\/strong> is the chairman of the\u00a0Associazione Alessandro Liberati, Network Italiano Cochrane, the Italian network linked to the Cochrane Collaboration.<\/em><\/p>\n<p>Competing interests: None.<\/p>\n<p><em><strong>Tom Jefferson<\/strong>, reviewer, Cochrane Acute Respiratory Infections Group, 00187, Rome, Italy<\/em>.<\/p>\n<p>Competing interests: TJ was a co-recipient of a UK National Institute for Health Research grant (HTA \u2013 10\/80\/01 Update and amalgamation of two Cochrane Reviews: neuraminidase inhibitors for preventing and treating influenza in healthy adults and children\u2014<a href=\"http:\/\/www.nets.nihr.ac.uk\/projects\/hta\/108001\">http:\/\/www.nets.nihr.ac.uk\/projects\/hta\/108001<\/a>).<\/p>\n<p>In addition: TJ receives royalties from his books published by Blackwells and Il Pensiero Scientifico Editore, Rome. TJ is occasionally interviewed by market research companies for anonymous interviews about Phase 1 or 2 pharmaceutical products. In 2011-2013, TJ acted as an expert witness in a litigation case related to oseltamivir phosphate; Tamiflu [Roche] and in a labour case on influenza vaccines in healthcare workers in Canada. In 1997-99 TJ acted as consultant for Roche, in 2001-2 for GSK, and in 2003 for Sanofi-Synthelabo for pleconaril (an anti-rhinoviral which did not get approval from the FDA). TJ was a consultant for IMS Health in 2013, and in 2014 was retained as a scientific adviser to a legal team acting on the drug Tamiflu (oseltamivir, Roche).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>European regulatory agencies frequently inform doctors and pharmacists about their activities, paying particular attention to pharmacovigilance. The Italian Medicines Agency (AIFA) started a new information feed on 3 April 2012: [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-33098","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ\" \/>\n<meta property=\"og:description\" content=\"European regulatory agencies frequently inform doctors and pharmacists about their activities, paying particular attention to pharmacovigilance. The Italian Medicines Agency (AIFA) started a new information feed on 3 April 2012: [...]More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/\" \/>\n<meta property=\"og:site_name\" content=\"The BMJ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/bmjdotcom\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-01-05T15:46:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-01-05T15:53:06+00:00\" \/>\n<meta name=\"author\" content=\"BMJ\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:site\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"BMJ\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/\"},\"author\":{\"name\":\"BMJ\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/person\\\/ba3da426ed20e8f1d933ca367d8216fe\"},\"headline\":\"Luca De Fiore and Tom Jefferson: Pills from the world\",\"datePublished\":\"2015-01-05T15:46:13+00:00\",\"dateModified\":\"2015-01-05T15:53:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/\"},\"wordCount\":571,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/\",\"name\":\"Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#website\"},\"datePublished\":\"2015-01-05T15:46:13+00:00\",\"dateModified\":\"2015-01-05T15:53:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2015\\\/01\\\/05\\\/pills-from-the-world\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Luca De Fiore and Tom Jefferson: Pills from the world\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\",\"name\":\"The BMJ\",\"description\":\"Helping doctors make better decisions.\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\",\"name\":\"The BMJ\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/files\\\/2018\\\/05\\\/The-BMJ-logo.jpg\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/files\\\/2018\\\/05\\\/The-BMJ-logo.jpg\",\"width\":852,\"height\":568,\"caption\":\"The BMJ\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/bmjdotcom\\\/\",\"https:\\\/\\\/x.com\\\/bmj_latest\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/person\\\/ba3da426ed20e8f1d933ca367d8216fe\",\"name\":\"BMJ\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"caption\":\"BMJ\"},\"sameAs\":[\"https:\\\/\\\/blogs.bmj.com\\\/\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/author\\\/admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/","og_locale":"en_US","og_type":"article","og_title":"Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ","og_description":"European regulatory agencies frequently inform doctors and pharmacists about their activities, paying particular attention to pharmacovigilance. The Italian Medicines Agency (AIFA) started a new information feed on 3 April 2012: [...]More...","og_url":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/","og_site_name":"The BMJ","article_publisher":"https:\/\/www.facebook.com\/bmjdotcom\/","article_published_time":"2015-01-05T15:46:13+00:00","article_modified_time":"2015-01-05T15:53:06+00:00","author":"BMJ","twitter_card":"summary_large_image","twitter_creator":"@bmj_latest","twitter_site":"@bmj_latest","twitter_misc":{"Written by":"BMJ","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/"},"author":{"name":"BMJ","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/person\/ba3da426ed20e8f1d933ca367d8216fe"},"headline":"Luca De Fiore and Tom Jefferson: Pills from the world","datePublished":"2015-01-05T15:46:13+00:00","dateModified":"2015-01-05T15:53:06+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/"},"wordCount":571,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/","url":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/","name":"Luca De Fiore and Tom Jefferson: Pills from the world - The BMJ","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#website"},"datePublished":"2015-01-05T15:46:13+00:00","dateModified":"2015-01-05T15:53:06+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/bmj\/2015\/01\/05\/pills-from-the-world\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/bmj\/"},{"@type":"ListItem","position":2,"name":"Luca De Fiore and Tom Jefferson: Pills from the world"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/bmj\/#website","url":"https:\/\/blogs.bmj.com\/bmj\/","name":"The BMJ","description":"Helping doctors make better decisions.","publisher":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/bmj\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/bmj\/#organization","name":"The BMJ","url":"https:\/\/blogs.bmj.com\/bmj\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/05\/The-BMJ-logo.jpg","contentUrl":"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/05\/The-BMJ-logo.jpg","width":852,"height":568,"caption":"The BMJ"},"image":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/bmjdotcom\/","https:\/\/x.com\/bmj_latest"]},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/person\/ba3da426ed20e8f1d933ca367d8216fe","name":"BMJ","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","caption":"BMJ"},"sameAs":["https:\/\/blogs.bmj.com\/"],"url":"https:\/\/blogs.bmj.com\/bmj\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/33098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/comments?post=33098"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/33098\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media?parent=33098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/categories?post=33098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/tags?post=33098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}