{"id":31697,"date":"2014-06-03T10:12:39","date_gmt":"2014-06-03T09:12:39","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=31697"},"modified":"2014-06-03T10:12:39","modified_gmt":"2014-06-03T09:12:39","slug":"the-bmj-today-high-hopes-legal-highs-and-pharmaceutical-hype","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2014\/06\/03\/the-bmj-today-high-hopes-legal-highs-and-pharmaceutical-hype\/","title":{"rendered":"The BMJ Today: High hopes\u2014legal highs and pharmaceutical hype"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/files\/2014\/03\/tom_moberly.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-31282\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2014\/03\/tom_moberly.jpg\" alt=\"tom_moberly\" width=\"160\" height=\"130\" \/><\/a><em>The BMJ<\/em>\u2019s readers are used to maintaining scepticism in the face of hype and hyperbole, and two new articles suggest that\u00a0this\u00a0is a healthy position to maintain.<\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/348\/bmj.g3647\">Rory Watson reports<\/a> on the growing number of new psychoactive substances, or \u201clegal highs,\u201d recognised by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). The number of new drugs recognised by the centre grew by 30% in 2013, as more than 81 new molecules were recognised in a single year. This means that, each year, the number of new \u201clegal highs\u201d produced is now more than double the number of new drugs registered by the global pharmaceutical industry.<!--more--><\/p>\n<p>The promise of extraordinary experiences from taking these substances has led those manufacturing and promoting these products to target the main segments of the drug market. But assessment by the centre\u2019s scientific committee has revealed that, whatever claims are made about efficacy and safety, these substances can be potent and harmful.<\/p>\n<p>The hype surrounding the development of new therapeutic drugs is examined in an <a href=\"http:\/\/www.bmj.com\/content\/348\/bmj.g3611\">Observations piece<\/a> by Ray Moynihan. He asks whether the flu drug zanamivir was \u201ca breakthrough or money for old rope,\u201d highlighting claims that the drug would be \u201cone of the greatest discoveries of the 20th century\u201d and a \u201cbreakthrough as significant as penicillin.\u201d<\/p>\n<p>Moynihan describes how, at a meeting in 1999, a medical officer at the US Food and Drug Administration had warned of the challenges of establishing the best way to measure the effect of a flu drug. At the same meeting the administration\u2019s statistical reviewer questioned not only how well the drug worked, but whether it worked in any meaningful way at all.<\/p>\n<p>Given subsequent assessments of the drug\u2019s effectiveness, such as <a href=\"http:\/\/www.bmj.com\/content\/348\/bmj.g2547\">a Cochrane review<\/a> that found a \u201cmarginal benefit\u201d of zanamivir, the administration would have done well to listen more closely to those individuals\u2019 sceptical position.<\/p>\n<p><em><strong>Tom Moberly<\/strong>\u00a0is careers editor for The BMJ<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The BMJ\u2019s readers are used to maintaining scepticism in the face of hype and hyperbole, and two new articles suggest that\u00a0this\u00a0is a healthy position to maintain. Rory Watson reports on [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2014\/06\/03\/the-bmj-today-high-hopes-legal-highs-and-pharmaceutical-hype\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5750],"tags":[],"class_list":["post-31697","post","type-post","status-publish","format-standard","hentry","category-the-bmj-today"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The BMJ Today: High hopes\u2014legal highs and pharmaceutical hype  - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2014\/06\/03\/the-bmj-today-high-hopes-legal-highs-and-pharmaceutical-hype\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The BMJ Today: High hopes\u2014legal highs and pharmaceutical hype  - The BMJ\" \/>\n<meta property=\"og:description\" content=\"The BMJ\u2019s readers are used to maintaining scepticism in the face of hype and hyperbole, and two new articles suggest that\u00a0this\u00a0is a healthy position to maintain. 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