{"id":270,"date":"2007-07-02T15:32:10","date_gmt":"2007-07-02T14:32:10","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2007\/07\/02\/arch-intern-med-25-jun-2007-vol-167\/"},"modified":"2007-07-02T15:32:10","modified_gmt":"2007-07-02T14:32:10","slug":"arch-intern-med-25-jun-2007-vol-167","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2007\/07\/02\/arch-intern-med-25-jun-2007-vol-167\/","title":{"rendered":"Arch Intern Med  25 Jun 2007  Vol 167"},"content":{"rendered":"<p>Here is a cohort study suggesting that older women who take <a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/abstract\/167\/12\/1240\">serotonin reuptake inhibitors show double the rate of hip bone loss<\/a> compared with those who take tricyclic antidepressants. <!--more--><br \/>\n<a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/abstract\/167\/12\/1246\">The same appears to apply to older men<\/a>, and the loss of vertebral bone is even greater. So much for the chalky end-points: now we need some hard ones. Someone needs to collect figures on fracture rates. In the mean time, be aware of this possibly significant drawback to such drugs, particularly in frail old ladies (see <a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/extract\/167\/12\/1231\">editorial<\/a>).<\/p>\n<p>Do sex hormones help men live longer? The straightforward answer from the <a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/abstract\/167\/12\/1252\">Massachusetts Male Aging Study<\/a> is no. They may in fact tend to make men die sooner, mainly as a result of a small increase in ischaemic heart disease and respiratory disease in the highest centiles of free testosterone.<\/p>\n<p>I\u2019ve never been to Canada, but perhaps plate sizes there are similar to those in the USA, i.e. gross and obesogenic, like the food placed on them. This <a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/abstract\/167\/12\/1277\">Canadian trial<\/a> simply gave obese patients with type 2 diabetes smaller plates to eat off: they lost weight and many needed less medication.<\/p>\n<p><a href=\"http:\/\/archinte.ama-assn.org\/cgi\/content\/abstract\/167\/12\/1284\">This trial gives a rather untimely plug for rosiglitazone<\/a> at low dosage, combined with insulin therapy in type 2 diabetes. It reduced HbA1c by 0.3% without short-term ill-effects, but it\u2019s not a strategy that could possibly be recommended until someone has crunched more numbers about these drugs and cardiovascular risk.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here is a cohort study suggesting that older women who take serotonin reuptake inhibitors show double the rate of hip bone loss compared with those who take tricyclic antidepressants. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2007\/07\/02\/arch-intern-med-25-jun-2007-vol-167\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111],"tags":[],"class_list":["post-270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Arch Intern Med 25 Jun 2007 Vol 167 - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2007\/07\/02\/arch-intern-med-25-jun-2007-vol-167\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Arch Intern Med 25 Jun 2007 Vol 167 - The BMJ\" \/>\n<meta property=\"og:description\" content=\"Here is a cohort study suggesting that older women who take serotonin reuptake inhibitors show double the rate of hip bone loss compared with those who take tricyclic antidepressants. 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