{"id":26687,"date":"2013-05-29T16:40:28","date_gmt":"2013-05-29T15:40:28","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=26687"},"modified":"2014-10-29T12:37:11","modified_gmt":"2014-10-29T11:37:11","slug":"wim-weber-on-open-the-european-research-project-to-study-publication-bias","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2013\/05\/29\/wim-weber-on-open-the-european-research-project-to-study-publication-bias\/","title":{"rendered":"Wim Weber on OPEN\u2014the European research project to study publication bias"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/2013\/05\/29\/wim-weber-on-open-the-european-research-project-to-study-publication-bias\/wim_weber\/\" rel=\"attachment wp-att-26736\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-26736\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2013\/05\/wim_weber.jpg\" alt=\"wim_weber\" width=\"160\" height=\"160\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2013\/05\/wim_weber.jpg 160w, https:\/\/blogs.bmj.com\/bmj\/files\/2013\/05\/wim_weber-150x150.jpg 150w\" sizes=\"auto, (max-width: 160px) 100vw, 160px\" \/><\/a>On 23 and 24 May the final workshop of the OPEN project took place in Freiburg, Germany. <a href=\"http:\/\/www.open-project.eu\/\">OPEN\u2014To Overcome failure to Publish nEgative fiNdings<\/a>\u2014is an EU funded project to study publication bias in medical research. It brings together research groups from Germany, Italy, France, Croatia, Spain, and the UK, and it aimed to assess the extent of the problem and come up with recommendations for the European Commission.<!--more--><\/p>\n<p>The quality of clinical trials has improved over the years, but publication bias has emerged as a major obstacle for a fair assessment of drugs and devices in medicine. When only trials with welcome results are published, we are still left with a false impression as to the true effect of an intervention.\u00a0 The <a href=\"http:\/\/en.wikipedia.org\/wiki\/Bad_Pharma\">pharmaceutical industry has faced massive criticism<\/a> here, but it is also present in <a href=\"http:\/\/www.bmj.com\/content\/346\/bmj.f105\">academia<\/a>.<\/p>\n<p>The OPEN project is coordinated by the German Cochrane Centre in Freiburg and it hosted this final workshop summarising the findings and we spent one day finalising recommendations. This is a difficult problem to study: how do you analyse something that is not there, i.e. non-publication. Most research by the OPEN group was through surveys, and it is safe to assume that the problem is vastly underreported. But even then, the findings are quite sobering:<\/p>\n<p>One third of surveyed medical researchers have unpublished data\u201420% cite methodological problems for non-publication.<\/p>\n<p>Less than half of surveyed European ethical committees ask for trial registration or check that approved studies are published.<\/p>\n<p>When using trial registries, ethics approval, and congress abstracts as denominator, less than half of medical research is published.<\/p>\n<p>More than half of European research funding bodies say they encourage publication of funded research, but two thirds do not bother to check this.<\/p>\n<p>Almost half of surveyed pharmaceutical companies reported having work rejected by journals for the sole reason of being industry funded.<\/p>\n<p>More than two thirds of surveyed medical journals does not require trial registration, as they see it as a &#8220;competitive disadvantage.&#8221;<\/p>\n<p>Regulatory bodies in most European countries do not take publication bias into account when assessing new drugs or devices.<\/p>\n<p>Recommendations will be summarised in a final document, but will certainly include obligatory trial registration before ethics approval and legal requirements to disseminate results from clinical studies.<\/p>\n<p><em><strong>Wim Weber<\/strong> is European research editor of the BMJ.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>On 23 and 24 May the final workshop of the OPEN project took place in Freiburg, Germany. OPEN\u2014To Overcome failure to Publish nEgative fiNdings\u2014is an EU funded project to study [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2013\/05\/29\/wim-weber-on-open-the-european-research-project-to-study-publication-bias\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[116],"tags":[],"class_list":["post-26687","post","type-post","status-publish","format-standard","hentry","category-editors-at-large"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Wim Weber on OPEN\u2014the European research project to study publication bias - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2013\/05\/29\/wim-weber-on-open-the-european-research-project-to-study-publication-bias\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Wim Weber on OPEN\u2014the European research project to study publication bias - The BMJ\" \/>\n<meta property=\"og:description\" content=\"On 23 and 24 May the final workshop of the OPEN project took place in Freiburg, Germany. 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