{"id":265,"date":"2007-06-24T12:37:50","date_gmt":"2007-06-24T11:37:50","guid":{"rendered":"http:\/\/resource.bmj.com\/bmj\/2007\/06\/24\/lancet-23-jun-2007-vol-369\/"},"modified":"2007-06-24T12:37:50","modified_gmt":"2007-06-24T11:37:50","slug":"lancet-23-jun-2007-vol-369","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2007\/06\/24\/lancet-23-jun-2007-vol-369\/","title":{"rendered":"Lancet  23 Jun 2007  Vol 369"},"content":{"rendered":"<p>Diastolic dysfunction is a diabolically dysfunctional subject: scarcely any two accounts agree, and the very mention of it can cause British cardiologists to foam at the mouth. <!--more-->I spent ages about ten years ago trying to devise a study of the natural history of hypertension in relation to left ventricular hypertrophy, diastolic filling, aortic pressure wave velocity and B-type natriuretic peptide release, oddly enough with the aim of using valsartan as the intervention. As a result I became a better and wiser person, but these investigators actually did the trial (<a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673607609805\/abstract\">VALIDD<\/a>). All they have discovered so far is that any blood pressure lowering agent improves diastolic filling velocity.<\/p>\n<p>Neurodegeneration will get us all in the end. Actually, I\u2019ve probably got the tense wrong in that sentence. Wouldn\u2019t it be marvellous if you could introduce the right genes to the cells concerned and reverse the process? This paper describes initial success in 12 patients with advanced Parkinson\u2019s disease, using a <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673607609829\/abstract\">glutamic acid decarboxylase (GAD) gene carried by an adenovirus vector<\/a>. Lots of bigger trials must surely follow.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diastolic dysfunction is a diabolically dysfunctional subject: scarcely any two accounts agree, and the very mention of it can cause British cardiologists to foam at the mouth. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2007\/06\/24\/lancet-23-jun-2007-vol-369\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":38363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111],"tags":[],"class_list":["post-265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-richard-lehmans-weekly-review-of-medical-journals"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lancet 23 Jun 2007 Vol 369 - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2007\/06\/24\/lancet-23-jun-2007-vol-369\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lancet 23 Jun 2007 Vol 369 - The BMJ\" \/>\n<meta property=\"og:description\" content=\"Diastolic dysfunction is a diabolically dysfunctional subject: scarcely any two accounts agree, and the very mention of it can cause British cardiologists to foam at the mouth. 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