{"id":16975,"date":"2012-05-09T17:31:35","date_gmt":"2012-05-09T16:31:35","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=16975"},"modified":"2012-05-09T17:31:35","modified_gmt":"2012-05-09T16:31:35","slug":"deborah-cohen-9-may-17h30-wheres-the-data-depuy","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2012\/05\/09\/deborah-cohen-9-may-17h30-wheres-the-data-depuy\/","title":{"rendered":"Deborah Cohen 9 May 17h30: Where\u2019s the data, DePuy?"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.bmj.com\/site\/blog\/icons\/debs.jpg\" alt=\"Deborah Cohen\" width=\"160\" height=\"160\" align=\"left\" \/> Back in February, the <em>BMJ<\/em> reported that a whole class of implant\u2014in this case large diameter metal-on-metal total hip replacement\u2014was allowed to enter the global market without any clinical studies to assess their safety and effectiveness. Hundreds of thousands of patients around the world may have been exposed to toxic metal ions released from the hips and the potential risks from this that have been known and well documented for decades.<!--more--><\/p>\n<p>The article drew a range of responses. Some surgeons were angry as they felt the resurfacing technique had been wrongly drawn in.\u00a0 It wasn\u2019t\u2014the feature clearly stated that it worked well in certain groups of patients. Patients also wrote in to question why hip replacements were allowed to continue to be sold when it was known that irreversible damage could occur.<\/p>\n<p>Graham Isaacs and Simon Sinclair responded on behalf of DePuy, which manufactures one of the products featured in the article..\u00a0The company took exception to the &#8220;alarmist&#8221; nature of the feature and offered an explanation of events in the feature. You can read the reply <a title=\"rapid response from DePuy\" href=\"http:\/\/www.bmj.com\/content\/344\/bmj.e1410\/rr\/578762\">here<\/a>:<\/p>\n<p>In turn, the <em>BMJ<\/em> <a title=\"BMJ response to DePuy\" href=\"http:\/\/www.bmj.com\/content\/344\/bmj.e1410\/rr\/582471\">responded<\/a> with\u00a0very detailed\u00a0follow up letter containing further information. This\u00a0allowed for further exploration of the problems that seem pervasive in medical implant regulation. This included a lack of independent studies; surgical trends with little evidence underpinning them; conflicts of interest pervading the published literature; and a lack of transparency to name but a few.<\/p>\n<p>However, what is particularly apparent is how, once again, the medical literature can not be relied upon to give an answer. Despite it being recognised &#8220;that one of the effects of having metal bearing surfaces would be that constituents of cobalt and chromium would be released locally and systemically&#8221;, very little in the published literature to date deals in detail with these concerns.<\/p>\n<p><strong>Deborah Cohen<\/strong> is investigations editor, BMJ<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Back in February, the BMJ reported that a whole class of implant\u2014in this case large diameter metal-on-metal total hip replacement\u2014was allowed to enter the global market without any clinical studies [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2012\/05\/09\/deborah-cohen-9-may-17h30-wheres-the-data-depuy\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[116],"tags":[],"class_list":["post-16975","post","type-post","status-publish","format-standard","hentry","category-editors-at-large"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Deborah Cohen 9 May 17h30: Where\u2019s the data, DePuy? 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