{"id":13419,"date":"2011-12-16T12:30:01","date_gmt":"2011-12-16T11:30:01","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=13419"},"modified":"2011-12-16T12:30:01","modified_gmt":"2011-12-16T11:30:01","slug":"research-highlights-16-december-2011","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2011\/12\/16\/research-highlights-16-december-2011\/","title":{"rendered":"Research highlights &#8211; 16 December 2011"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.bmj.com\/site\/blog\/icons\/research-methods-and-reporting.jpg\" alt=\"Research questions\" width=\"160\" height=\"110\" align=\"left\" \/>&#8221; &#8220;Research highlights&#8221; is a weekly round-up of research papers appearing in the print BMJ. We start off with this week\u2019s research questions, before providing more detail on some individual research papers and accompanying articles.<!--more--><\/p>\n<ul>\n<li><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7281\">Do statins lower risk of infections?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7163\">How do risk models and scores for predicting type 2 diabetes in adults perform in practice?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7157\">Does a delay in clamping the umbilical cord affect infant haemoglobin and iron status in a European setting?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d6891\">Is non-alcoholic fatty liver disease associated with mortality in a US sample?<\/a><\/li>\n<\/ul>\n<p><strong>Scores for predicting type 2 diabetes in adults<br \/>\n<\/strong>\u201cApplication of prognostic models requires unambiguous definitions of predictors and reproducible measurements using methods available in clinical practice\u201d concluded Karel Moons and colleagues in the last part of their BMJ series on prognostic research (<a href=\"http:\/\/www.bmj.com\/content\/338\/bmj.b606\"><em>BMJ<\/em> 2009;338:b606<\/a>). Douglas Noble and colleagues have now reinforced and extended that argument with their <a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7163\">systematic and realist review<\/a> of published prognostic scores for type 2 diabetes and related follow-up studies assessing usability and impact.<!--more--><\/p>\n<p>There\u2019s no shortage of such scores: the authors\u2019 extensive search found 145 examples and they studied 94 in detail. Many scores had been well developed and validated and were technically sound. But few, concluded the authors, are usable in real life. Indeed, just seven of the scores met their criteria for having high potential for use in practice and improving patients\u2019outcomes.<br \/>\nOne of the reviewers for this paper said \u201cperhaps the greatest value of this review is to document an approach for mapping and evaluating the growing number of tools. The authors demur from selecting a single best instrument\u2014as they rightly argue, usefulness depends on context.\u201d She also thought that readers might be reassured to see this validation of their \u201cfeelings of perplexity at the growing number of clinical scales and scores that they may be expected to use.\u201d<\/p>\n<p><strong><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7157\">Effects of delayed cord clamping in Western settings<br \/>\n<\/a><\/strong>Delaying clamping of the umbilical cord after a baby is born allows placental blood to flow to the infant, and this placental transfusion increases the total blood volume of a term infant by about 30%. In developing countries with a high prevalence of iron deficiency anaemia, such delayed cord clamping has been shown to improve iron status in infants within the first months of life, but in Western countries with a low prevalence of iron deficiency anaemia it has been suggested that delayed clamping might lead to over-transfusion and result in polycythaemia, hyperviscosity syndrome, or hyperbilirubinaemia.<\/p>\n<p>To clarify the situation, Ola Andersson and colleagues undertook this <a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7157\">randomised clinical trial<\/a> to compare the effects of delayed and early cord clamping in 400 healthy, term Swedish infants.\u00a0 They found that delayed clamping (\u2265180 seconds after delivery) improved iron status and decreased the risk for iron deficiency at 4 months of age compared with early clamping (\u226410 seconds after delivery) and was not associated with neonatal jaundice or other adverse effects.\u00a0 The authors conclude that further study is warranted to establish the long term effects of delayed cord clamping, particularly on neurodevelopment, which can be impaired by iron deficiency.<\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7127\">In his linked editorial<\/a> Patrick van Rheenen looks at the reasoning and assumptions behind the widespread adoption of early cord clamping in Western medicine and concludes that this study by Andersson and colleagues \u201cis convincing enough to encourage a change of practice.\u201d Indeed, judging from the online responses to the full paper on bmj.com\u2014almost universally positive and mainly from obstetricians asking about practical details of the procedure\u2014the article has sparked considerable interest.<\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/343\/bmj.d7679\"><strong>How fast does the Grim Reaper walk?<\/strong><br \/>\n<\/a>Fiona Stanaway and colleagues estimate how fast older men might have to walk in order to avoid death (doi:10.1136\/bmj.d7679).<\/p>\n<p><strong>Is the BMJ the right journal for your research?<br \/>\n<\/strong>We give priority to articles reporting original, robust research studies that can improve decision making in medical practice, policy, or education, or in future research. But we receive many more research articles than we can publish, send fewer than half for external peer review, and currently accept only around 7%.<\/p>\n<p>We appreciate that authors don\u2019t want to waste time by sending work to the wrong journal, and we can\u2019t always answer every emailed presubmission inquiry, so we hope that our checklist will help you decide whether the BMJ is the right place for your work (<a href=\"http:\/\/www.bmj.com\/about-bmj\/resources-authors\">http:\/\/www.bmj.com\/about-bmj\/resources-authors<\/a>). If you think the BMJ is the right journal for your research, please ensure that you\u2019ve followed our full advice\u00a0 and then submit your article at: <a href=\"http:\/\/submit.bmj.com\">http:\/\/submit.bmj.com<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8221; &#8220;Research highlights&#8221; is a weekly round-up of research papers appearing in the print BMJ. We start off with this week\u2019s research questions, before providing more detail on some individual [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2011\/12\/16\/research-highlights-16-december-2011\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2744,1978,643,2743],"class_list":["post-13419","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-non-alcoholic-fatty-liver-disease","tag-statins","tag-type-2-diabetes","tag-umbilical-cord"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research highlights - 16 December 2011 - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2011\/12\/16\/research-highlights-16-december-2011\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research highlights - 16 December 2011 - The BMJ\" \/>\n<meta property=\"og:description\" content=\"&#8221; &#8220;Research highlights&#8221; is a weekly round-up of research papers appearing in the print BMJ. 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