{"id":7404,"date":"2017-10-03T02:37:55","date_gmt":"2017-10-03T01:37:55","guid":{"rendered":"https:\/\/blogs.bmj.com\/bjsm\/?p=7404"},"modified":"2017-10-03T02:38:12","modified_gmt":"2017-10-03T01:38:12","slug":"temporal-considerations-endocrinemetabolic-interactions-part-2","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bjsm\/2017\/10\/03\/temporal-considerations-endocrinemetabolic-interactions-part-2\/","title":{"rendered":"Temporal considerations in Endocrine\/Metabolic interactions Part 2"},"content":{"rendered":"

By<\/strong>\u00a0Dr Nicky Keay<\/strong><\/a><\/p>\n

As discussed in the\u00a0first part\u00a0of this blog series, the\u00a0Endocrine system<\/a>\u00a0displays temporal variation in release of hormones. Amplitude and frequency of hormonal secretion display a variety of time-related patterns. Integrating external lifestyle factors with this internal, intrinsic temporal dimension is crucial for supporting metabolic and Endocrine health and sport performance.<\/p>\n

\"\"Circadian misalignment and sedentary lifestyle has been implicated in the increased incidence of metabolic syndrome driven by insulin resistance and associated\u00a0metabolic inflexibility<\/a>\u00a0and decrease in fat oxidation. However, a recent\u00a0study<\/a>\u00a0of overweight individuals, found that increases in fat oxidation from lifestyle intervention, corresponded to different clinical outcomes. Both those who maintained weight loss and those who regained weight displayed increased fat oxidation compared to baseline. How could this be? Increased fat oxidation is only part of the equation in overall fat balance. What adaptations in the metabolic and Endocrine networks were occurring during rest periods? In the case of those that maintained weight loss, increased fat oxidation was reflected in biochemical and physiological adaptations to enable this process. Whereas for those that regained weight in the long term, increased fat oxidation was enabled by increased availability of lipids, indicating increased fat synthesis over degradation.<\/p>\n

Clearly there is individual variation in long-term Endocrine and metabolic responses to external factors. Focusing on optimising a single aspect of metabolism in the short term, will not necessarily produce the expected, or desired clinical outcome over a sustained period of time. As previously discussed the single most effective lifestyle change that induces synchronised, beneficial sustained Endocrine and metabolic adaptations is\u00a0exercise<\/a>.<\/p>\n

It will come as no surprise that focusing on maximising use of a single substrate in metabolism, without integration into a seasonal training plan and consideration of impacts on internal control networks, has not produced the desired outcome of improved performance amongst\u00a0athletes<\/a>. Theoretically, increasing fat oxidation will benefit endurance athletes by sparing glycogen use for high intensity efforts. Nutritional ketosis can be endogenous (carbohydrate restricted intake) or exogenous (ingestion of ketone esters and carbohydrate). Low carbohydrate\/high fat diets have been shown in numerous studies to increase fat oxidation, however, this was at the expense of effective glucose metabolism required during high intensity efforts. Potentially there could be adverse effects of low carbohydrate intake on gut microbiota and immunity.<\/p>\n

This effect was observed even in a study on a short timescale using a blinded, placebo-controlled\u00a0exogenous ketogenic intervention<\/a>\u00a0during a bicycle test, where glycogen was available as a substrate. The proposed mechanism is that although ketogenic diets promote fat oxidation, this down-regulates glucose use, as a respiratory substrate. In addition, fat oxidation carries a higher oxygen demand for a lower yield of ATP, compared to glucose as a substrate in oxidative phosphorylation.<\/p>\n

Metabolic flexibility<\/a>\u00a0the ability to use a range of substrates according to requirement, is key for health and sport performance. For example, during high intensity phases of an endurance race, carbohydrate will need to be taken on board, so rehearsing what types\/timing of such nutrition works best for an individual athlete in some training sessions is important. Equally, some low intensity training sessions with low carbohydrate intake could encourage metabolic flexibility. However, in a\u00a0recent study<\/a>\u00a0\u201ctraining low\u201d or periodised carbohydrate intake failed to confer a performance advantage. I would suggest that the four week study time frame, which was not integrated into the overall training season plan, is not conclusive as to whether favourable long term Endocrine and metabolic adaptations would occur. A\u00a0review<\/a>\u00a0highlighted seasonal variations in male and female athletes in terms of energy requirements for different training loads and body composition required for phases of training blocks and cycles over a full training season.<\/p>\n

Essentially an integrated periodisation of training, nutrition and recovery over a full training season will optimise the desired Endocrine and metabolic adaptations for improved sport-specific performance. The emphasis will vary over the\u00a0lifespan of the individual<\/a>. The intricately synchronised sequential\u00a0Endocrine control<\/a>\u00a0of the female menstrual cycle is particularly sensitive to external perturbations of nutrition, exercise and recovery. Unfortunately the majority of research studies focus on male subjects.<\/p>\n

In all scenarios, the same fundamental temporal mechanisms are in play. The body seeks to maintain homeostasis: status quo of the internal milieu is the rule. Any external lifestyle factors provoke short term internal responses, which are regulated by longer term\u00a0Endocrine network responses<\/a>\u00a0to result in metabolic and physiological adaptations.<\/p>\n

For further discussion on Health, Hormones and Human Performance, come to the BASEM annual conference<\/a><\/p>\n

 <\/p>\n

References<\/strong><\/p>\n

Temporal considerations in Endocrine\/Metabolic interactions Part 1\u00a0<\/a>Dr N. Keay<\/p>\n

Sports Endocrinology \u2013 what does it have to do with performance?<\/a>\u00a0Dr N.Keay, British Journal of Sports Medicine 2017<\/p>\n

Sedentary behaviour is a key determinant of metabolic inflexibility\u00a0<\/a>Journal of Physiology 2017<\/p>\n

Influence of maximal fat oxidation on long-term weight loss maintenance in humans<\/a>\u00a0Journal of Applied Physiology 2017<\/p>\n

One road to Rome: Metabolic Syndrome, Athletes, Exercise\u00a0<\/a>Dr N.Keay 2017<\/p>\n

Metabolic and Endocrine System Networks<\/a>Dr N. Keay 2017<\/p>\n

Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males<\/a>\u00a0Applied Physiology, Nutrition, and Metabolism 2017<\/p>\n

Endocrine system: balance and interplay in response to exercise training\u00a0<\/a>Dr N. Keay 2017<\/p>\n

No Superior Adaptations to Carbohydrate Periodization in Elite Endurance Athletes<\/a>\u00a0Medicine & Science in Sports & Exercise 2017<\/p>\n

Total Energy Expenditure, Energy Intake, and Body Composition in Endurance Athletes Across the Training Season: A Systematic Review\u00a0<\/a>Sports Medicine \u2013 Open 2017<\/p>\n

Successful Ageing<\/a>\u00a0Dr N. Keay, British Association of Sport and Exercise Medicine 2017<\/p>\n

Optimal Health: For All Athletes! Part 4 \u2013 Mechanisms\u00a0<\/a>Dr N. Keay, British Association of Sport and Exercise Medicine 2017<\/p>\n

 <\/p>\n

 <\/p>\n

Keywords<\/strong>: \u00a0athletes<\/a>,\u00a0Biochronometry<\/a>,\u00a0diet<\/a>,\u00a0Endocrine<\/a>,exercise<\/a>,\u00a0fitness<\/a>,\u00a0health<\/a>,\u00a0hormones<\/a>,\u00a0ketogenic diet<\/a>,\u00a0lifespan<\/a>,\u00a0lifestyle<\/a>,\u00a0metabolic flexibility<\/a>,metabolic syndrome<\/a>,\u00a0metabolism<\/a>,\u00a0nutrition<\/a>,performance<\/a>,\u00a0physiology<\/a>,\u00a0REDs<\/a>,\u00a0sleep<\/a>,\u00a0sport<\/a>,training<\/a>,\u00a0training season<\/a><\/p>\n

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By\u00a0Dr Nicky Keay As discussed in the\u00a0first part\u00a0of this blog series, the\u00a0Endocrine system\u00a0displays temporal variation in release of hormones. Amplitude and frequency of hormonal secretion display a variety of time-related patterns. Integrating external lifestyle factors with this internal, intrinsic temporal dimension is crucial for supporting metabolic and Endocrine health and sport performance. Circadian misalignment and […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[16061,16059],"class_list":["post-7404","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-circadian-rhythm","tag-endocrine-system"],"yoast_head":"\nTemporal considerations in Endocrine\/Metabolic interactions Part 2 - BJSM blog - social media's leading SEM voice<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bjsm\/2017\/10\/03\/temporal-considerations-endocrinemetabolic-interactions-part-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Temporal considerations in Endocrine\/Metabolic interactions Part 2 - BJSM blog - social media's leading SEM voice\" \/>\n<meta property=\"og:description\" content=\"By\u00a0Dr Nicky Keay As discussed in the\u00a0first part\u00a0of this blog series, the\u00a0Endocrine system\u00a0displays temporal variation in release of hormones. 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