{"id":11549,"date":"2025-04-07T06:00:03","date_gmt":"2025-04-07T05:00:03","guid":{"rendered":"https:\/\/blogs.bmj.com\/bjsm\/?p=11549"},"modified":"2026-03-04T09:20:38","modified_gmt":"2026-03-04T08:20:38","slug":"recognising-and-managing-popliteal-artery-entrapment-syndrome-a-concise-overview-for-physiotherapists","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bjsm\/2025\/04\/07\/recognising-and-managing-popliteal-artery-entrapment-syndrome-a-concise-overview-for-physiotherapists\/","title":{"rendered":"Recognising and Managing Popliteal Artery Entrapment Syndrome A Concise Overview for Physiotherapists"},"content":{"rendered":"<p><span style=\"font-weight: 400\">Popliteal Artery Entrapment Syndrome (PAES), first described in 1965, involves neuromuscular and ischemic symptoms caused by pathologic impingement of the popliteal artery (PA), with or without the involvement of the popliteal vein, and tibial nerve in the popliteal fossa (1).<\/span> <span style=\"font-weight: 400\">Compression commonly involves the medial head of the gastrocnemius muscle and may be congenital or acquired through muscular hypertrophy (2).<\/span> <span style=\"font-weight: 400\">PAES has an estimated incidence of 0.17% to 3.5%, with approximately 85% of cases affecting males, predominantly athletes under 30 years old (2).<\/span><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The median delay in diagnosis is 12 months, with reports of misdiagnosis lasting up to 15 years due to the young age of patients, lack of atherosclerotic risk factors, and similarity to other lower limb conditions. If undiagnosed, it can progress to chronic complications, including arterial occlusion, critical limb ischemia, aneurysm formation, or even amputation (3).<\/span><\/p>\n<h4>Types of PAES<\/h4>\n<ol>\n<li style=\"font-weight: 400\"><b>Anatomical PAES<\/b><span style=\"font-weight: 400\">: Involves a defined anatomical lesion causing compression and occlusion of the popliteal artery. Is typically unilateral in nature (2, 3).<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Functional PAES (FPAES)<\/b><span style=\"font-weight: 400\">: Characterised by evidence of PA occlusion without a clear anatomical lesion. Often bilateral, with the medial head of the gastrocnemius muscle contributing to crowding in the popliteal fossa. Functional compression occurs in 30% to 50% of the general population and can affect both trained and untrained individuals (2, 3).<\/span> <span style=\"font-weight: 400\">The plantaris muscle is another overlooked culprit for vascular compression.\u00a0<\/span><\/li>\n<\/ol>\n<p><em><strong>Figure 1. Popliteal Artery Entrapment Classification System (3).<\/strong><\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11550\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.46-300x110.png\" alt=\"\" width=\"496\" height=\"182\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.46-300x110.png 300w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.46-768x281.png 768w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.46-640x234.png 640w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.46.png 1210w\" sizes=\"auto, (max-width: 496px) 100vw, 496px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11551\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.57-300x98.png\" alt=\"\" width=\"496\" height=\"162\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.57-300x98.png 300w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.57-768x251.png 768w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.57-640x209.png 640w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.09.57.png 1212w\" sizes=\"auto, (max-width: 496px) 100vw, 496px\" \/><\/p>\n<h4>Signs and Symptoms<span style=\"font-weight: 400\">\u00a0<\/span><\/h4>\n<p><span style=\"font-weight: 400\">PAES typically presents with (typically one of or a combination of the following)\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-11552 alignright\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.08-216x300.png\" alt=\"\" width=\"216\" height=\"300\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.08-216x300.png 216w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.08.png 502w\" sizes=\"auto, (max-width: 216px) 100vw, 216px\" \/><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Calf cramping &amp; tightness\/fullness, swelling, paraesthesia into the feet and toes, coldness, or loss of distal pulses with exertion.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ache deep in the calf after exercise\/calf loading or prolonged postures.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Key aggravators: calf-loading exercises, uphill walking, stair climbing, hiking, running, sustained plantarflexion, or prolonged standing.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">In some cases, pressing a car accelerator may also provoke symptoms.<\/span><\/li>\n<\/ul>\n<h4>Differential Diagnosis<span style=\"font-weight: 400\">\u00a0<\/span><\/h4>\n<p><span style=\"font-weight: 400\">PAES can mimic conditions like chronic exertional compartment syndrome (CECS) and other vascular or musculoskeletal disorders. Distinguishing between anatomical and functional PAES requires further investigation, as clinical symptoms alone are insufficient. Other lower limb vascular conditions to consider include External Iliac Artery Endofibrosis and deep vein thrombosis (2, 3, 4).<\/span><\/p>\n<p><em><strong>Figure 2.<span style=\"font-size: 1rem\"> Differential diagnosis and clinical features of exertional leg pain. Adapted and modified from Hislop et al. 2014 (2)<\/span><\/strong><\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11553\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.36-300x260.png\" alt=\"\" width=\"640\" height=\"554\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.36-300x260.png 300w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.36-768x666.png 768w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.36-640x555.png 640w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.10.36.png 1128w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/p>\n<h4>Physio-Specific Assessment<\/h4>\n<ul>\n<li style=\"font-weight: 400\"><b>Subjective<\/b><span style=\"font-weight: 400\">: History of exercise or posture-induced calf pain with matching symptoms.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Objective<\/b><span style=\"font-weight: 400\">:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><b>Observation<\/b><span style=\"font-weight: 400\">: Redness, swelling, increased tone or discoloration of the calf\/foot at rest or post-exertion.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Gait<\/b><span style=\"font-weight: 400\">: Increased plantarflexion tendencies during push-off.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Functional Tests<\/b><span style=\"font-weight: 400\">: Progression from double-leg calf raises to single-leg hops and running\/incline treadmill walking while monitoring symptoms.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Palpation<\/b><span style=\"font-weight: 400\">: Evaluate atypical muscle bulk in the popliteal fossa during prone plantarflexion contraction.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Pedal Pulse<\/b><span style=\"font-weight: 400\">: Check at rest and during sustained plantarflexion, using auscultation if needed.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i><span style=\"font-weight: 400\">Note<\/span><\/i><span style=\"font-weight: 400\">: Clinical examination alone cannot diagnose PAES.<\/span><\/p>\n<p><b>Referral for further investigations: <\/b><span style=\"font-weight: 400\">Patients should be referred to a sports physician for diagnostic testing, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400\"><b>Provocative Doppler Ultrasound<\/b><span style=\"font-weight: 400\">: Pre-and post-exercise to assess blood flow (2).<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Ankle-Brachial Index (ABI)<\/b><span style=\"font-weight: 400\">: Evaluates peripheral vascular disease but has limitations in PAES.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Functional MR Angiogram<\/b><span style=\"font-weight: 400\">: Provides detailed vascular imaging.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Compartment Pressure Testing<\/b><span style=\"font-weight: 400\">: May co-exist with PAES which can blur the clinical picture, especially as intercompartmental pressures may not correlate with symptoms (5).<\/span><\/li>\n<\/ul>\n<p><b>Treatment Options<\/b><\/p>\n<ol>\n<li style=\"font-weight: 400\"><b>Non-Operative<\/b><span style=\"font-weight: 400\">:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><b>Botulinum Toxin A (BTA)<\/b><span style=\"font-weight: 400\">: First-line treatment for FPAES. Injected into the culprit musculature under electromyographic guidance. Proposed benefits include:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Muscle paralysis to alleviate dynamic arterial occlusion.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Localised muscle atrophy to create more space for vessels.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Possible vasodilation of the popliteal artery (2, 6).<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Success rates exceed 50%, with risks lower than surgery. Treatment typically involves 1\u20133 sessions, with potential follow-ups. Case reports highlight successful return to sport with strategic BTA use in season (7).<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400\"><b>Surgical Intervention<\/b><span style=\"font-weight: 400\">:<\/span>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Surgery depends on the PAES subtype and symptoms. Early intervention focuses on musculotendinous release, while advanced cases may require arterial bypass (3, 8).<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For <\/span><b>Anatomical PAES<\/b><span style=\"font-weight: 400\">, procedures include myotomy of the medial head of the gastrocnemius, re-routing of the artery, and additional decompression for complex cases.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For <\/span><b>Functional PAES<\/b><span style=\"font-weight: 400\">, options include myotomy, fasciotomy, plantaris muscle excision, and other decompressive techniques.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Long-term recurrence in FPAES may result from fibrosis around the neurovascular bundle.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p><strong><em>Image 2. Intraoperative image of my right leg during a MHGM myotomy, with removal measuring 15cm long and 4cm wide.\u00a0<\/em><\/strong><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11554\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.11.00-213x300.png\" alt=\"\" width=\"361\" height=\"508\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.11.00-213x300.png 213w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/Screenshot-2025-04-06-at-16.11.00.png 506w\" sizes=\"auto, (max-width: 361px) 100vw, 361px\" \/><\/p>\n<h4>Post-Treatment Considerations<span style=\"font-weight: 400\">\u00a0<\/span><\/h4>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Validated methods for assessing post-operative outcomes are lacking (6). Some studies measure return-to-sport rates or changes in exercise ABI. Long-term follow-up may be necessary to monitor recurrence and address fibrosis-related issues (6).<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">My clinical opinion is that creatine supplementation and the use of blood flow restriction training should not be used in those with PAES. Careful re-loading of the calf musculature post-op e.g., only doing seated calf raises with modified rep-ranges may reduce the chance of muscular redevelopment post-op.\u00a0<\/span><\/li>\n<\/ul>\n<h4><b><br \/>\n<\/b>Conclusion<\/h4>\n<ul>\n<li style=\"font-weight: 400\"><b>Recognising PAES<\/b><span style=\"font-weight: 400\">: PAES is an important differential diagnosis for chronic exertional leg pain. It is commonly missed, leading to delays in diagnosis and treatment.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Management<\/b><span style=\"font-weight: 400\">: Understanding the appropriate referral pathways and treatment options is crucial when presented with a PAES patient. Consider Botulinum Toxin A for functional cases and surgery for anatomical cases, with careful rehab post-op to prevent recurrence.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For a concise audio summary of PAES, click <a href=\"https:\/\/open.spotify.com\/episode\/0m5DNtQjDXeMulNkVp7460?si=01cb4f7762e147a4\">here<\/a> to listen to podcast on Spotify.<\/span><\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11555\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/PAES-Physios-review-240x300.png\" alt=\"\" width=\"545\" height=\"681\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/PAES-Physios-review-240x300.png 240w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/PAES-Physios-review-768x960.png 768w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/PAES-Physios-review-640x800.png 640w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/04\/PAES-Physios-review.png 1080w\" sizes=\"auto, (max-width: 545px) 100vw, 545px\" \/><\/p>\n<h5>Author<\/h5>\n<p><span style=\"font-weight: 400\">Mr. Angus Shaw \u2013 Physiotherapist. Special interest in the assessment and diagnosis of chronic exertional lower leg pain. Angus brings a unique perspective on the topic of chronic exertional leg pain having had personal experience with the condition (4 x FPAES operations and 11 x fasciotomies for CECS). a.shaw680@gmail.com.\u00a0<\/span><span style=\"font-weight: 400\"><br \/>\n<\/span><span style=\"font-weight: 400\"><br \/>\n<\/span><span style=\"font-weight: 400\">No Competing Interests\u00a0<\/span><\/p>\n<h5>References<\/h5>\n<ol>\n<li style=\"list-style-type: none\">\n<ol>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Turnipseed WD. Popliteal entrapment syndrome. Journal of Vascular Surgery. 2002 May 1;35(5):910-5. <\/span><span style=\"font-weight: 400\">doi:10.1067\/mva.2002.125364.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hislop M, Tierney P, Murray D. Functional popliteal artery entrapment syndrome: a review. J Sports Med. 2014;48(5):435-43. doi:10.1177\/0363546514559282.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hameed M, Teh J, Sinha S. Popliteal artery entrapment syndrome: diagnosis and management. Br J Sports Med. 2018;52(7):459-64. doi:10.1136\/bjsports-2016-096421.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Brewer RB, Gregory AJM. Chronic Lower Leg Pain in Athletes: A Guide for the Differential Diagnosis, Evaluation, and Treatment.\u00a0<\/span><i><span style=\"font-weight: 400\">Sports Health<\/span><\/i><span style=\"font-weight: 400\">. 2012;4(2):121-127. doi:<\/span><a href=\"https:\/\/doi.org\/10.1177\/1941738111426115\"><span style=\"font-weight: 400\">10.1177\/1941738111426115<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Zimmermann WO, Behrens M, Fischer A, et al. Intracompartmental pressure and exercise pain. Transl J ACSM. 2018;3(9):125-30. doi:10.1249\/TJX.0000000000000072.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Lovelock T, Firth J, Hamilton B. Functional PAES: diagnosis and management. Int J Sports Med. 2021;42(3):205-11. doi:10.1055\/a-1211-5206.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Murphy M, Brennan M, Rankin A. Botulinum toxin injection in functional PAES. Phys Ther Sport. 2017;25:92-6. doi:10.1016\/j.ptsp.2016.12.008.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Bradshaw S, O\u2019Neill D, Fitzpatrick A. Popliteal artery entrapment syndrome. Cardiovasc Diagn Ther. 2021;11(5):1234-42. doi:10.21037\/cdt-21-44.<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Popliteal Artery Entrapment Syndrome (PAES), first described in 1965, involves neuromuscular and ischemic symptoms caused by pathologic impingement of the popliteal artery (PA), with or without the involvement of the popliteal vein, and tibial nerve in the popliteal fossa (1). Compression commonly involves the medial head of the gastrocnemius muscle and may be congenital or [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bjsm\/2025\/04\/07\/recognising-and-managing-popliteal-artery-entrapment-syndrome-a-concise-overview-for-physiotherapists\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":464,"featured_media":11555,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[16386,16068,16387],"class_list":["post-11549","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-chronic-exertional-leg-pain","tag-featured","tag-popliteal-artery-entrapment-syndrome"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Recognising and Managing Popliteal Artery Entrapment Syndrome A Concise Overview for Physiotherapists - BJSM blog - social media&#039;s leading SEM voice<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bjsm\/2025\/04\/07\/recognising-and-managing-popliteal-artery-entrapment-syndrome-a-concise-overview-for-physiotherapists\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recognising and Managing Popliteal Artery Entrapment Syndrome A Concise Overview for Physiotherapists - BJSM blog - social media&#039;s leading SEM voice\" \/>\n<meta property=\"og:description\" content=\"Popliteal Artery Entrapment Syndrome (PAES), first described in 1965, involves neuromuscular and ischemic symptoms caused by pathologic impingement of the popliteal artery (PA), with or without the involvement of the popliteal vein, and tibial nerve in the popliteal fossa (1). 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