{"id":11437,"date":"2025-01-06T16:11:03","date_gmt":"2025-01-06T15:11:03","guid":{"rendered":"https:\/\/blogs.bmj.com\/bjsm\/?p=11437"},"modified":"2025-01-06T16:11:03","modified_gmt":"2025-01-06T15:11:03","slug":"hiit-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bjsm\/2025\/01\/06\/hiit-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis\/","title":{"rendered":"HIIT &#8211; feasible, well tolerated, and beneficial in patients with rheumatoid arthritis"},"content":{"rendered":"<h3>Why is this study important?<\/h3>\n<p><span style=\"font-weight: 400\">Patients with rheumatoid arthritis (RA) have an elevated risk of cardiovascular diseases compared with the general population. Their higher risk is linked to the systemic inflammatory process in combination with increased levels of traditional risk factors, for example hypertension, <\/span><span style=\"font-weight: 400\">hyperlipidemia, high body mass index and smoking.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">Physical activity and cardiorespiratory fitness are inversely associated with an adverse cardiovascular disease risk profile in RA. This means that people with RA who are physically active and have better fitness are at a lower risk of heart disease. However, many patients with RA are not active on a high enough intensity level to improve cardiorespiratory fitness.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">In a recent study summarised in this blog, we aimed to evaluate the effects of high-intensity interval training (HIIT) and strength exercise, tailor-made for patients with RA, on cardiovascular and physical health by a randomized controlled multicenter trial.<\/span><\/p>\n<h3>How did the study go about this?<\/h3>\n<p><span style=\"font-weight: 400\">The patients<\/span><span style=\"font-weight: 400\">, n=87, <\/span><span style=\"font-weight: 400\">mean age 48.1 (SD 9.66) years<\/span><span style=\"font-weight: 400\"> from rheumatology units in western Sweden<\/span><span style=\"font-weight: 400\"> were randomly assigned into an exercise group or a control group. Patients in the exercise group performed 12 weeks supervised HIIT exercise. Each session included\u00a0 alternating bouts of high intensity intervals (90-95% of heart rate maximum) with periods of lower intensity. This was followed by strength exercise of large muscle groups, <\/span><span style=\"font-weight: 400\">such as<\/span><span style=\"font-weight: 400\"> leg press, squat, hip extension, pull down, biceps curl, rows to chest, sit ups and lumbar back extension<\/span><span style=\"font-weight: 400\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The patients in the control group received individual information on the general recommendations of physical activity with encouragement to be active on a moderate intensity level of at least 150 min per week. <\/span><span style=\"font-weight: 400\">A rigorous safety screening of contradictions to participate in high-intensity exercise was performed on all patients prior to inclusion.<\/span><\/p>\n<h3>What did the study find?<\/h3>\n<p><span style=\"font-weight: 400\">We found that supervised high-intensity interval training (HIIT) and strength exercise for 12 weeks significantly improved cardiorespiratory fitness (VO<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\"> max), waist circumference, muscle strength, and overall health. Importantly, the intervention did not worsen disease activity and RA symptoms including pain\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The mean treatment effect of 3.7 mL\/ kg\/min in VO<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\">max, corresponding to 12.6% difference in change, indicates substantial health-related gains for the patients in the exercise group.\u00a0<\/span><\/p>\n<h3>What are the key take-home points?<\/h3>\n<p><span style=\"font-weight: 400\">Supervised HIIT and strength exercise in combination appear to be feasible and well tolerated and could be recommended as a treatment option to improve cardiovascular and physical health in patients with well-controlled RA.<\/span><\/p>\n<p><span style=\"font-weight: 400\">We strongly recommend pre-exercise safety screening before start-up of any high intensity aerobic exercise.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/bjsm.bmj.com\/content\/58\/23\/1409\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11438\" src=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2-300x300.png\" alt=\"\" width=\"572\" height=\"572\" srcset=\"https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2-300x300.png 300w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2-150x150.png 150w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2-768x768.png 768w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2-640x640.png 640w, https:\/\/blogs.bmj.com\/bjsm\/files\/2025\/01\/HIIT-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis-2.png 1080w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4>Author and Affiliations:<\/h4>\n<p><span style=\"font-weight: 400\">Annelie Bilberg, Jan Bjersing, Mats B\u00f6rjesson, Eva Klingberg, Kaisa Mannerkorpi, Jenny Sivertsson, Sara Svedlund.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Associate professor, PhD Annelie Bilberg, Institute of Neuroscience, Department of Health and Rehabilitation, Gothenburg University, Goteborg, Sweden<\/span><\/p>\n<p><span style=\"font-weight: 400\">annelie.bilberg@vgregion.se<\/span><\/p>\n<h4><span style=\"font-weight: 400\">References<\/span><\/h4>\n<ol>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Agca R, Heslinga SC, van Halm VP, et al. Atherosclerotic cardiovascular disease in patients with chronic inflammatory joint disorders. Heart 2016;102:790\u20135.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Agca R, Heslinga SC, Rollefstad S, et\u00a0al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015\/2016 update. Ann Rheum Dis 2017;76:17\u201328.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Hammam N, Ezeugwu VE, Rumsey DG, et al. Physical activity, sedentary behavior, and long-term cardiovascular risk in individuals with rheumatoid arthritis. Phys Sports med 2019;47:463\u201370.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u00a0Liff MH, Hoff M, Wisloff U, et al. Reduced cardiorespiratory fitness is a mediator of excess all-cause mortality in rheumatoid arthritis: the Tr\u00f8ndelag Health Study. RMD Open 2021;7:e001545.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Pelliccia A, Sharma S, Gati S, et\u00a0al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J 2021;42:17\u201396.<\/span><\/li>\n<\/ol>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why is this study important? Patients with rheumatoid arthritis (RA) have an elevated risk of cardiovascular diseases compared with the general population. Their higher risk is linked to the systemic inflammatory process in combination with increased levels of traditional risk factors, for example hypertension, hyperlipidemia, high body mass index and smoking.\u00a0 Physical activity and cardiorespiratory [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bjsm\/2025\/01\/06\/hiit-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":464,"featured_media":11438,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2683,655,16068,16366,16215,519],"class_list":["post-11437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-arthritis","tag-exercise","tag-featured","tag-high-intensity","tag-hiit","tag-training"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HIIT - feasible, well tolerated, and beneficial in patients with rheumatoid arthritis - BJSM blog - social media&#039;s leading SEM voice<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bjsm\/2025\/01\/06\/hiit-feasible-well-tolerated-and-beneficial-in-patients-with-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HIIT - feasible, well tolerated, and beneficial in patients with rheumatoid arthritis - BJSM blog - social media&#039;s leading SEM voice\" \/>\n<meta property=\"og:description\" content=\"Why is this study important? Patients with rheumatoid arthritis (RA) have an elevated risk of cardiovascular diseases compared with the general population. 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