{"id":967,"date":"2014-08-31T21:26:14","date_gmt":"2014-08-31T20:26:14","guid":{"rendered":"https:\/\/blogs.bmj.com\/adc\/?p=967"},"modified":"2014-08-31T21:26:14","modified_gmt":"2014-08-31T20:26:14","slug":"which-o-for-pico","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/adc\/2014\/08\/31\/which-o-for-pico\/","title":{"rendered":"Which O for PICO?"},"content":{"rendered":"<p><a href=\"http:\/\/www.comet-initiative.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"http:\/\/www.comet-initiative.org\/assets\/images\/logos\/comet-logo-small.png\" alt=\"\" width=\"168\" height=\"62\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>We&#8217;ve mentioned before about the <a title=\"What would Jack want?\" href=\"https:\/\/blogs.bmj.com\/adc\/2010\/03\/10\/what-would-jack-want\/\">COMET <\/a>initiative, that was born from lots of work in rheumatology, and seeks to standardise a core set of outcomes collected in clinical trials so that the trial<\/p>\n<ol>\n<li>Measures things of importance to patients, clinicians and researchers and<\/li>\n<li>Provides a degree of homogeneity that makes systematic reviews more powerful<\/li>\n<\/ol>\n<p>Well, those clever rheumatologists have done it again, conceptualising the whole of it into two major areas, and breaking them up into manageable parts.<\/p>\n<p><!--more--><\/p>\n<p>The paper, open access and relatively readable, is here but the key importance comes from<\/p>\n<p><a href=\"http:\/\/www.jclinepi.com\/article\/S0895-4356(13)00488-5\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/download.journals.elsevierhealth.com\/images\/journalimages\/0895-4356\/PIIS0895435613004885.gr1.lrg.jpg\" alt=\"\" width=\"539\" height=\"317\" \/><\/a><\/p>\n<p>The bubbling down of it is how does the condition affect the life of the patient; mortality, morbidity in its broadest sense, and the resources required in each arm of the trial. And then beyond that, how does the disease present itself to\u00a0the world &#8211; in surrogates, biomarkers, organ changes and measurable abnormalities.<\/p>\n<p>By setting a cornerstone on each of these elements, we can then make sure any trial helps patients understand the impact of the treatment upon them, clinicians appreciate what might be improved and the costs to be expended, and researchers look to see how the presumed pathology works in the reality of real people free living in the world.<\/p>\n<p>This won&#8217;t be retroactive, but like the <a href=\"http:\/\/www.consort-statement.org\/\">CONSORT statement <\/a>and the <a title=\"Trial registration. Free, easy and important.\" href=\"https:\/\/blogs.bmj.com\/adc\/2013\/12\/04\/trial-registration-free-easy-and-important\/\">requirement for trial registration<\/a>, it&#8217;s a step towards improving all trials in humans. Now if only someone would start a campaign to get <a href=\"http:\/\/www.alltrials.net\/\">AllTrials reported<\/a>\u00a0too &#8230;<\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; We&#8217;ve mentioned before about the COMET initiative, that was born from lots of work in rheumatology, and seeks to standardise a core set of outcomes collected in clinical trials so that the trial Measures things of importance to patients, clinicians and researchers and Provides a degree of homogeneity that makes systematic reviews more powerful [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/adc\/2014\/08\/31\/which-o-for-pico\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[79],"tags":[],"class_list":["post-967","post","type-post","status-publish","format-standard","hentry","category-archimedes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Which O for PICO? - ADC Online Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/adc\/2014\/08\/31\/which-o-for-pico\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Which O for PICO? - ADC Online Blog\" \/>\n<meta property=\"og:description\" content=\"&nbsp; We&#8217;ve mentioned before about the COMET initiative, that was born from lots of work in rheumatology, and seeks to standardise a core set of outcomes collected in clinical trials so that the trial Measures things of importance to patients, clinicians and researchers and Provides a degree of homogeneity that makes systematic reviews more powerful [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/adc\/2014\/08\/31\/which-o-for-pico\/\" \/>\n<meta property=\"og:site_name\" content=\"ADC Online Blog\" \/>\n<meta property=\"article:published_time\" content=\"2014-08-31T20:26:14+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.comet-initiative.org\/assets\/images\/logos\/comet-logo-small.png\" \/>\n<meta name=\"author\" content=\"Bob Phillips\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bob Phillips\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/\"},\"author\":{\"name\":\"Bob Phillips\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#\\\/schema\\\/person\\\/9e94029681ecf36e73bbd1eb2be2ef94\"},\"headline\":\"Which O for PICO?\",\"datePublished\":\"2014-08-31T20:26:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/\"},\"wordCount\":252,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.comet-initiative.org\\\/assets\\\/images\\\/logos\\\/comet-logo-small.png\",\"articleSection\":[\"archimedes\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2014\\\/08\\\/31\\\/which-o-for-pico\\\/\",\"name\":\"Which O for PICO? 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