{"id":21,"date":"2008-12-22T17:44:27","date_gmt":"2008-12-22T16:44:27","guid":{"rendered":"https:\/\/blogs.bmj.com\/adc-archimedes\/2007\/11\/22\/question-aciclovir-for-herpetic-gingivostomatisis\/"},"modified":"2009-03-01T13:14:03","modified_gmt":"2009-03-01T12:14:03","slug":"question-aciclovir-for-herpetic-gingivostomatisis","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/adc\/2008\/12\/22\/question-aciclovir-for-herpetic-gingivostomatisis\/","title":{"rendered":"Give Aciclovir for herpetic gingivostomatisis"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/bob_phillips.allmail.net\/ACV.png\" alt=\"ACV molecule\" width=\"82\" height=\"100\" align=\"right\" \/>Does oral aciclovir improve clinical outcome in immunocompetent children with primary herpes simplex gingivostomatitis?<\/strong><\/p>\n<p>A 3 year old previously well boy presents with a fever of 38.6\u00bac and several ulcers and erosions extending from his lips, along the tongue and cheek, to the back of the throat. The lesions have all appeared within the last 2 days. He has been crying inconsolably over the past 24 hours and is refusing food and drink. Is the use of oral aciclovir is indicated for primary herpes gingivostomatitis in children?<\/p>\n<p><!--more-->The question has been posed by a team from University Hospital of Wales, in Cardiff.  It&#8217;s my belief that aciclovir works (based on clinical experience in children with malignant disease) &#8211; but the question of &#8216;is it indicated&#8217; asks more than just &#8216;does it work&#8217; but &#8216;should we use it&#8217;?<\/p>\n<p>Any views out there?<\/p>\n<p>(You can review the evidence in the report <a title=\"Archimedes Report\" href=\"http:\/\/adc.bmj.com\/cgi\/content\/extract\/94\/2\/165-a\">here<\/a>.)<\/p>\n<p>Acknowledgement:<\/p>\n<p>Image from <a title=\"Original Source\" href=\"http:\/\/commons.wikimedia.org\/wiki\/Image:Aciclovir-3D-vdW.png\">Wikipedia<\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Does oral aciclovir improve clinical outcome in immunocompetent children with primary herpes simplex gingivostomatitis? A 3 year old previously well boy presents with a fever of 38.6\u00bac and several ulcers and erosions extending from his lips, along the tongue and cheek, to the back of the throat. The lesions have all appeared within the last [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/adc\/2008\/12\/22\/question-aciclovir-for-herpetic-gingivostomatisis\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[156,153,157,82],"tags":[],"class_list":["post-21","post","type-post","status-publish","format-standard","hentry","category-aciclovir","category-answered","category-hsv","category-therapy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Give Aciclovir for herpetic gingivostomatisis - ADC Online Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/adc\/2008\/12\/22\/question-aciclovir-for-herpetic-gingivostomatisis\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Give Aciclovir for herpetic gingivostomatisis - ADC Online Blog\" \/>\n<meta property=\"og:description\" content=\"Does oral aciclovir improve clinical outcome in immunocompetent children with primary herpes simplex gingivostomatitis? A 3 year old previously well boy presents with a fever of 38.6\u00bac and several ulcers and erosions extending from his lips, along the tongue and cheek, to the back of the throat. The lesions have all appeared within the last [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/adc\/2008\/12\/22\/question-aciclovir-for-herpetic-gingivostomatisis\/\" \/>\n<meta property=\"og:site_name\" content=\"ADC Online Blog\" \/>\n<meta property=\"article:published_time\" content=\"2008-12-22T16:44:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2009-03-01T12:14:03+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/bob_phillips.allmail.net\/ACV.png\" \/>\n<meta name=\"author\" content=\"Bob Phillips\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bob Phillips\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/\"},\"author\":{\"name\":\"Bob Phillips\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#\\\/schema\\\/person\\\/9e94029681ecf36e73bbd1eb2be2ef94\"},\"headline\":\"Give Aciclovir for herpetic gingivostomatisis\",\"datePublished\":\"2008-12-22T16:44:27+00:00\",\"dateModified\":\"2009-03-01T12:14:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/\"},\"wordCount\":157,\"commentCount\":2,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#organization\"},\"articleSection\":[\"aciclovir\",\"answered\",\"HSV\",\"therapy\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2008\\\/12\\\/22\\\/question-aciclovir-for-herpetic-gingivostomatisis\\\/\",\"name\":\"Give Aciclovir for herpetic gingivostomatisis - 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