{"id":101,"date":"2010-05-09T21:15:22","date_gmt":"2010-05-09T20:15:22","guid":{"rendered":"https:\/\/blogs.bmj.com\/adc-archimedes\/2010\/05\/09\/do-children-and-adults-really-differ\/"},"modified":"2013-03-15T17:16:29","modified_gmt":"2013-03-15T16:16:29","slug":"do-children-and-adults-really-differ","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/","title":{"rendered":"Do children and adults really differ?"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" title=\"Three UK Party Leaders\" src=\"http:\/\/www.independent.co.uk\/multimedia\/archive\/00250\/brown-cameron-clegg_250220s.jpg\" alt=\"\" width=\"198\" height=\"135\" \/> @giordanopg recently tweeted a link about a <a title=\"Comparative Effectiveness of Medical Interventions in Adults Versus Children\" href=\"http:\/\/bit.ly\/9ik9kP\">paper <\/a>in pre-publication from The Journal Of Pediatrics. It&#8217;s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question &#8220;Do children and adults really differ?&#8221;<\/p>\n<p>Their technique was to compare the key outcomes by comparing the odds ratios &#8230; and they found that for the majority of cases THERE WAS NO OBSERVABLE DIFFERENCE (overall relative odds ratio 0.96; 95% confidence intervals, 0.86 to 1.08)<!--more--><br \/>\nThis does hide the fact that in only 1 \/ 127 could it be said there was very unlikely to be a difference (ie no more than 20% better or worse), and that in 4 \/ 127 there was evidence of a real, clinically important difference.<br \/>\nHow we read this, I think, depends on where we sit. Do we want to lump &#8230; and draw down adult evidence &#8230; or do we want to particularise, and require truly direct evidence? (Or do we go for a Balanced Parliament and have a bit of both with electoral reform thrown in?)<\/p>\n<p>Acknowledgement: Picture from the Online Independent<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>@giordanopg recently tweeted a link about a paper in pre-publication from The Journal Of Pediatrics. It&#8217;s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question &#8220;Do children and adults really differ?&#8221; Their technique was to compare the key outcomes by comparing [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[79,80],"tags":[1639],"class_list":["post-101","post","type-post","status-publish","format-standard","hentry","category-archimedes","category-critical-appraisal-note","tag-archimedes-critical-appriasal-note"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Do children and adults really differ? - ADC Online Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Do children and adults really differ? - ADC Online Blog\" \/>\n<meta property=\"og:description\" content=\"@giordanopg recently tweeted a link about a paper in pre-publication from The Journal Of Pediatrics. It&#8217;s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question &#8220;Do children and adults really differ?&#8221; Their technique was to compare the key outcomes by comparing [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/adc\/2010\/05\/09\/do-children-and-adults-really-differ\/\" \/>\n<meta property=\"og:site_name\" content=\"ADC Online Blog\" \/>\n<meta property=\"article:published_time\" content=\"2010-05-09T20:15:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-03-15T16:16:29+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.independent.co.uk\/multimedia\/archive\/00250\/brown-cameron-clegg_250220s.jpg\" \/>\n<meta name=\"author\" content=\"Bob Phillips\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bob Phillips\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/\"},\"author\":{\"name\":\"Bob Phillips\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#\\\/schema\\\/person\\\/9e94029681ecf36e73bbd1eb2be2ef94\"},\"headline\":\"Do children and adults really differ?\",\"datePublished\":\"2010-05-09T20:15:22+00:00\",\"dateModified\":\"2013-03-15T16:16:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/\"},\"wordCount\":182,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.independent.co.uk\\\/multimedia\\\/archive\\\/00250\\\/brown-cameron-clegg_250220s.jpg\",\"keywords\":[\"Archimedes; critical appriasal note\"],\"articleSection\":[\"archimedes\",\"critical appraisal note\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/adc\\\/2010\\\/05\\\/09\\\/do-children-and-adults-really-differ\\\/\",\"name\":\"Do children and adults really differ? 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