When being overweight pays off!

Factors influencing mortality in ALS are clearly multifactorial.  The ability to determine these factors and subsequently modify them could be of therapeutic significance in ALS.  The large EPIC cohort recently established that a higher body mass index may be neuroprotective, i.e. reduce mortality in ALS, which was evident in both males and females.  This association […]

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Cortical atrophy in ALS related to cognitive dysfunction. Food for thought?

Cortical atrophy, as assessed by novel volumetric MRI techniques, have revealed inconsistent results in ALS.  Specifically, while cortical thinning, predominantly within the motor/frontal lobe regions, have been reported by some, absence of atrophy has been reported by others.  Mioshi and colleagues elegantly demonstrate a potential explanation for such discordant MRI findings.  Namely, ALS patients with […]

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MS and ALS: A common pathophysiological denominator?

Ismail and colleagues report on a high concurrence rate of multiple sclerosis (MS) and ALS.  Interestingly, the C9orf72 expansion was identified in 80% of the ALS-MS patients.  Given that the inflammatory system appears to be deregulated in patients expressing the c9orf72 expansion, with down-regulation of the neuroprotective CXCL10 chemokine and dysfunction of NF-kB activity,   the […]

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When chocolate does not taste sweet!

Omar and colleagues identified abnormalities in processing and identification of common flavors in patients with frontotemporal lobe syndromes.  This loss of flavor processing was associated with atrophy of the left entorhinal cortex, hippocampus, parahippocampal gyrus and temporal pole.  From a clinical perspective, these findings provide insights into abnormal eating behavior patterns in FTD and ultimately […]

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Do patient ratings of symptoms match functional improvements in Parkinson’s Disease?

  It may seem strange, but asking patients with Parkinson’s disease to rate how much their symptoms have improved doesn’t seem to match up to clinical improvements, at least as assessed by using the conventional symptoms scores used by clinical researchers.   Doctors and researchers use different symptom scores to help measure the symptoms of […]

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Launch of a new cover – JNNP in 2013!

   Medical publishing metrics and financial yields In “Chapters from My Autobiography” published in 1906, Mark Twain noted that “figures often beguile me, particularly when I have the arranging of them myself; in which case the remark attributed to Disraeli would often apply with justice and force: ‘There are three kinds of lies: lies, damned […]

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Can an app diagnose visual problems and monitor your recovery?

Introduction     A web app has been developed that can test the eyesight of people with conditions that cause vision loss – particularly stroke.   Hemianopia is a condition that causes a loss of vision in either the right or left sides of both eyes. It is a common side effect of stroke. Less […]

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