Another nail in the preverbial coffin for CCSVI theory?

Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as a potential pathogenic mechanism in MS.  While pathological data to support such a theory were elusive, a world-wide craze was sett-off, mostly amongst patients, some vascular physicians and some (minority) of neurologist.  It seamed appealing that a simple vascular problem was responsible for MS, but alas subsequent […]

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The Sound of Music

My sister is doing a degree in music.  I listen, fascinated, to her stories; music school isn’t like med school.  Their days begin around noon, fellow students sport wild hair colours and outfits (tutus anyone?), and the last exam she sat was held upstairs in the local pub.   Image credit: http://www.keepcalm-o-matic.co.uk/p/study-your-exam-and-have-a-beer–1/   Most people enjoy […]

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Sleepy heads

It’s 1.30am, Friday morning.  I’m struggling to keep awake on the first night shift of the year.  One down (well half of it anyway), six more to go.  I’m a light sleeper at the best of times, however, after a busy med reg night shift, it’s a different story.  I’ve slept through our smoke alarm […]

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The New Wonder Drug

I’m currently working as a junior doctor in a subacute hospital, on the Neurology Ward. Our in-patients come in for symptom management, and sometimes end of life care. Conditions include motor neuron disease, Huntington’s disease, multiple sclerosis, and the Parkinson Plus ‘three ugly sisters’ (although I’ve only seen MSA & PSP in my time here). […]

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Non-contiguous propagation of ALS: River of hyperexcitability?

The site of disease onset in ALS remains enigmatic, and resolution of this quandary could shed light of ALS pathogenesis and may be of therapeutic significance. Previous studies suggested a contiguous spread of disease, implying a role for local (spinal) factors in ALS pathogenesis. In contrast, Sekiguchi and colleagues report non-contiguous spread, a well observed […]

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