Central autoimmune channelopathies: a link between Neurology and Psychiatry

  Since the recognition of antibodies against voltage – gated potassium channel (VGKC) and their pathogenic implication in central nervous system disorders (such as limbic encephalitis) in 2001, critical immunological and neurological advances have been achieved during the last 15 years. One of the main discoveries has been that these VGKC antibodies usually target proteins […]

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Melatonin an effective alternative for migraine prevention

  In the current issue of JNNP, Gonçalves and colleagues have published a randomized control trial (RCT) comparing melatonin, amitriptyline and placebo for migraine prevention. Migraine is a chronic neurological disease and has been ranked as the sixth disabling condition by World Health Organization (WHO). The goals of migraine prophylaxis are to reduce migraine attacks, […]

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Revealing the molecular fingerprint of oligodendroglial tumours

  In the current issue of JNNP, Iwadate and colleagues investigated the correlation between the changes in 11C-methionine positron emission tomography (PET) and the 1p/19q status in oligodendroglial tumours. Gliomas are the most common primary brain tumour in adults. Typically, based in the histological classification, gliomas have been classified into two major subgroups: (i) astrocytic […]

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Titin: a new piece in the puzzle of ALS

  In the current issue of JNNP, Watanabe and colleagues published a genome-wide association study (GWAS) in ALS to explore the effects of genetic variants in the disease course of sporadic ALS patients. ALS is an incurable neurodegenerative disease that affects the motor neurons in the cortex, brainstem, and spinal cord, typically resulting in death […]

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Neuronal autoantibodies as a new enemy in temporal lobe epilepsy

  In the current issue of JNNP, Vanli-Yavuz and colleagues published the largest systematic screening study of neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Of relevance to the study, epilepsy is a prevalent neurological disorder affecting over 50 million people worldwide. Despite all the advances in this field, it is estimated […]

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Zika virus and neurological disease: is there evidence for causality?

Arun Krishnan and Steve Vucic, Neurologists and JNNP web editors, discuss recent data on possible Zika virus-induced neurological disease. There has been considerable worldwide coverage documenting the impact of the recent Zika virus epidemic which spread through South America and more recently the Carribean. While infection with Zika is of little consequence in most people […]

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Antibody-mediated encephalitis: new insights into diagnosis and treatment

Confusion is a common enough symptom in clinical practice. Often, it can be attributed to systemic conditions, such as medication side effects or infection. Occasionally however, one can be caught out in a situation where a patient develops confusion that is due to a more sinister and rare cause. Encephalitis is a rare cause of […]

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The obesity-stroke paradox: why do obese patients have milder strokes?

Over the weekend, the Sydney Morning Herald wrote of the ‘heavy cost’ of obesity to the Australian health system http://www.smh.com.au/nsw/the-heavy-cost-of-obesity-and-how-nsw-health-workers-are-responding-20150613-ghmxbu.html . The article featured a quote that “the new normal is to be overweight or obese”. The epidemic of obesity has presented major health challenges that are not just faced by the developed world but […]

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