Cholinesterase inhibitors in Parkinsons disease?

Cholinesterase inhibitors (ChIs) improve cholinergic transmission and thereby may lead to improved cognitive function in PD, although the risk of side-effects such as falls may be potentially increased.  In an upcoming issue of JNNP (On line first)  Pagano and colleagues conducted a meta-analysis to further assess these issues.  The results show a clear improvement of cognitive function in PD, without an increase in risk of falls, although the risk of tremor and adverse drug reactions was increased.

 

 

Read more at:  http://jnnp.bmj.com/content/early/2014/09/15/jnnp-2014-308764.abstract

 

J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2014-308764
  • Movement disorders
  • Research paper

Cholinesterase inhibitors for Parkinson’s disease: a systematic review and meta-analysis