Polycystic ovary syndrome (PCOS), characterized by menstrual irregularity, hyperandrogenism and polycystic ovarian morphology, is the most common endocrinopathy in reproductive-aged women leading to anovulatory infertility. Its clinical manifestations and complications are well elaborated while the pathogenesis is obscure. In the current study, the authors took advantage of recently published genome-wide association study and proceeded replication for the gene Yeast Associated Protein 1 (YAP1) – an important transcriptional co-activator. Finally, they proved YAP1 is a novel susceptibility gene for PCOS. (By Dr. Zi-Jiang Chen, http://jmg.bmj.com/content/49/4/254.abstract )