Many liver diseases are accompanied by yellow jaundice due to impaired elimination of bilirubin, which is generated from biliverdin through biliverdin reductase activity. Two cases of unrelated Inuit women from different geographic areas in Greenland suffering from episodes of green jaundice due to biliverdin accumulation associated with biliary obstruction are reported. A mutation in the gene encoding this enzyme was found in both patients and some relatives. This mutation accounts for a shorter than normal protein with no catalytic activity. Thus, the complete absence of biliverdin reductase results in a non-lethal condition and green jaundice if liver function is impaired. (By Dr. Jose J. G. Marin, http://jmg.bmj.com/content/early/2011/01/28/jmg.2009.074567?papetoc=)