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Glucose-Insulin-Potassium shows some benefit in acute coronary syndrome

6 Jul, 12 | by Alistair Lindsay

Intravenous glucose-insulin-potassium (GIK) is postulated to be beneficial in acute ischaemic syndromes via two mechanisms: by providing metabolic support to ischaemic myocardium, and by preventing arrhythmias and cardiac arrest due to ischaemia-related metabolic derangements.  Importantly, these benefits are most likely to be seen if GIK is started as soon as possible after the onset of myocardial ischaemia, therefore GIK should ideally be initiated in the out-of-hospital setting. more…

Early diagnosis of MI using serial troponin measurements

29 Dec, 11 | by Alistair Lindsay

The recent introduction of high sensitivity troponin assays (hsT) has improved the sensitivity of this assay for the detection of myocardial infarction, whilst simultaneously decreasing specificity.  To overcome this problem, the use of troponin kinetics – to identify acute myocardial damage  – has been proposed, either alone or in combination with other diagnostic markers of cardiovascular disease. more…

Novel diagnostic pathway improves chest pain assessment

4 Apr, 11 | by Alistair Lindsay

Although 75-85% of patients presenting to the emergency department with chest pain ultimately do not receive a diagnosis of acute coronary syndrome, a lengthy assessment process is still mandatory as patients with a missed diagnosis of myocardial infarction are at increased risk for a cardiovascular event.  Than et al. prospectively validated the safety of a predefined accelerated diagnostic protocol (ADP) aimed at assessing chest pain patients within two hours. more…

Fasting blood glucose levels identify high-risk individuals across the ACS spectrum

15 Apr, 09 | by Alistair Lindsay

Elevated blood glucose at hospital admission, and elevated fasting blood glucose levels during admission, have been shown to predict worse outcome among patients with STEMI, however, the contribution of glucose levels to risk predictive algorithms involving patients with acute coronary syndromes (ACS) remains unclear. more…

Fasting blood glucose levels identify high-risk individuals across the ACS spectrum

14 Apr, 09 | by Alistair Lindsay

Elevated blood glucose at hospital admission, and elevated fasting blood glucose levels during admission, have been shown to predict worse outcome among patients with STEMI, however, the contribution of glucose levels to risk predictive algorithms involving patients with acute coronary syndromes (ACS) remains unclear. more…

Assessing Risk in ACS – Risk Scores More Reliable

14 Mar, 09 | by Alistair Lindsay

How well do physicians assess risk in non-ST elevation (NSTEMI) acute coronary syndrome (ACS) patients? Recent studies have suggested that often high-risk patients are the ones who receive less aggressive therapy – the so called “treatment-risk paradox”. This study sought to identify the patient characteristics that physicians considered to be high-risk, and to examine how patient risk assessment by physicians related to objective risk score evaluation and eventual treatment. more…

Cardiogenic shock rates show evidence of decline

17 Jan, 09 | by Alistair Lindsay

It remains uncertain whether the sweeping changes in the treatment of acute coronary syndromes have had a substantial impact on the incidence of cardiogenic shock. more…

Highlighted articles from non-cardiological journals relevant to cardiology.

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