Decrease in risk of community sudden cardiac death over the last 30 years

Although several large clinical trials have recently examined the risk of sudden cardiac death after myocardial infarction (MI), community-based data reflecting the contemporary risk of sudden cardiac death after MI are lacking. Adabag et al. determined to evaluate the risk of sudden cardiac death after MI and the impact of recurrent ischemia and heart failure […]

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Effective Risk-Factor Reduction Could Eliminate Socioeconomic differences in cardiovascular health

A socioeconomic gradient in coronary mortality is well established in developed countries, and is becoming increasingly apparent in low- and middle-income countries too.  Previously, it has not been clear to what extent the classical cardiovascular risk factors are responsible for this difference, nor indeed whether by treating them effectively it could be possible to balance […]

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JUPITER puts primary prevention into new orbit

Current guidelines recommend statin treatment for patients with known vascular disease, diabetes or elevated lipid levels. Yet half of myocardial infarctions and strokes occur in apparently healthy individuals with levels of low density lipoprotein (LDL) cholesterol that are below current threshold levels for treatment. High sensitivity C-reactive protein (CRP) is an inflammatory biomarker which can […]

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Higher nonfasting triglycerides associated with ischaemic stroke risk

Two recent studies reported a strong association between elevated levels of nonfasting, but not fasting, triglycerides and increased risk of myocardial infarction, ischemic heart disease, and death and total cardiovascular events.  However, to date the evidence regarding the risk of nonfasting triglyceride levels has been less clear. […]

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VAD survival rate lower than expected in new analysis

In 2003 Medicare extended coverage of ventricular assist devices (VAD) as destination (permanent) therapy for end-stage heart failure in the USA.  Hernandez et al. performed an analysis to determine the short- and long-term clinical outcomes of patients receiving VAD therapy, as well as the costs involved, since this change. […]

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Thrombolysis in stroke: minutes mean mind

The current thrombolysis guidelines for acute ischaemic stroke recommend thrombolysis with alteplase initiated within 3 hours of symptom onset.  This was following the landmark findings of the 1995 National Institute of Neurological Disorders and Stroke (NINDS) study group.  The ECAS III trial (European Cooperative Acute Stroke Study), a multi-centre, randomised, placebo controlled phase 3 trial […]

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SEAS apart: no role for lipid lowering in aortic valve disease

Calcific aortic stenosis shares risk factors with coronary heart disease and predicts death and MI without the need for large gradients.  Hyperlipidaemia has been suggested as a risk factor for the development of aortic stenosis but to date lipid lowering studies have demonstrated conflicting results. […]

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