Higher nonfasting triglycerides associated with ischaemic stroke risk

Two recent studies reported a strong association between elevated levels of nonfasting, but not fasting, triglycerides and increased risk of myocardial infarction, ischemic heart disease, and death and total cardiovascular events.  However, to date the evidence regarding the risk of nonfasting triglyceride levels has been less clear. […]

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VAD survival rate lower than expected in new analysis

In 2003 Medicare extended coverage of ventricular assist devices (VAD) as destination (permanent) therapy for end-stage heart failure in the USA.  Hernandez et al. performed an analysis to determine the short- and long-term clinical outcomes of patients receiving VAD therapy, as well as the costs involved, since this change. […]

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Thrombolysis in stroke: minutes mean mind

The current thrombolysis guidelines for acute ischaemic stroke recommend thrombolysis with alteplase initiated within 3 hours of symptom onset.  This was following the landmark findings of the 1995 National Institute of Neurological Disorders and Stroke (NINDS) study group.  The ECAS III trial (European Cooperative Acute Stroke Study), a multi-centre, randomised, placebo controlled phase 3 trial […]

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SEAS apart: no role for lipid lowering in aortic valve disease

Calcific aortic stenosis shares risk factors with coronary heart disease and predicts death and MI without the need for large gradients.  Hyperlipidaemia has been suggested as a risk factor for the development of aortic stenosis but to date lipid lowering studies have demonstrated conflicting results. […]

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DES show mortality benefit in AMI

Currently both bare metal stents (BMS) and drug-eluting stents (DES) are used during percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).  PCI has been demonstrated to reduce the rate of death or recurrent ischaemia when compared to medical therapy.  To date trials comparing DES and BMS in acute MI have been limited by small […]

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ARIA suggests diagnostic angiography underused

Deciding which patients presenting with chest pain should undergo diagnostic coronary angiography (DCA) is an everyday dilemma for the cardiologist.  In the ARIA (Appropriateness of Referral and Invesigation of Angina) study, Hemingway and colleagues used scoring criteria, based on patient-specific characteristics and validated by 2 panels of experts made up of 22 UK physicians, in […]

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