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Evidence Live

Better Decisions Require More Affordable Treatments: Part 2

25 May, 16 | by BMJ Clinical Evidence

Carl Heneghanby Carl Heneghan

This blog was originally written for Evidence Live blogs and posted on evidencelive.org

Part 1 of this series pointed out we need better research to support better decisions. Market forces, though, may not be helping decision-making as new treatments – particularly drugs – are increasingly unaffordable and out of the reach of payers…

Estimates suggest the development of a newly approved drug currently costs around $2.6billion.  A high proportion of current costs are driven by high failure rates, the spiralling costs of clinical trials and competition with existing treatments that already have substantial effectiveness. As an example, Astra Zeneca’s five year drug development pipeline analysis reported only 2% of their products made it to market in this period: 59% of drugs completed Phase 1; only 15% completed Phase II, where most failures occurred and most improvement is required, and 60% completed Phase III. Whilst R&D costs have increased almost exponentially output has flatlined over the same time period. more…

Better Decisions Require Better Evidence: Part 1

25 May, 16 | by BMJ Clinical Evidence

Carl Heneghanby Carl Heneghan

The campaign starts at EvidenceLive 2016 – with  an open meeting to prioritise and explore the potential solutions to better evidence for better decisions.

This blog was originally written for Evidence Live blogs and posted on evidencelive.org

At the core of evidence-based medicine is the integration of patient values and high quality evidence. Informed patients should also understand their treatment options and actively participate in making decisions about their own health, and  to achieve this, clinicians require better research evidence. However, there are growing concerns that a sizeable amount of current published research is irrelevant, wasteful and detrimental to patient care. more…

How to get published?

20 May, 16 | by BMJ Clinical Evidence

Trish_Groves_resizedDavid M_blog
By Trish Groves and David Moher

In the run up to Evidence Live 2016, we are running a series of blogs by the speakers at the conference discussing what they will be speaking about at the conference….

The highlight of last year’s excellent Evidence Live was, for me (Trish Groves), a short, private conversation. Two doctors from Pakistan (a husband and wife) sought me out to say they had taken part in my Evidence Live workshop two years earlier, on how to publish research. They went on to complete their research and, for the first time, to successfully publish two papers. “BMJ helped us broaden our vision, and changed our lives” they said.

Similar stories, and a growing realisation that we all need to tackle the huge challenge of waste in research, inspired BMJ to develop Research to PublicationThis is a comprehensive eLearning programme for early career researchers. more…

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