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Pathology

Case report of Fibrous Dysplasia 120,000 years post mortem

6 Jun, 13 | by Dr Dean Jenkins

PLoS One has published archeological evidence of a possible primary rib cancer in a Neanderthal era human from over 120,000 years ago. (1)

This, clearly, is a very long time to wait for the publication of a case report!

The authors provide photographic and radiographic evidence of the tumour and presume it to be a primary bone tumour – fibrous dysplasia, “a benign disease of bone with rare potential for malignant transformation” (2). They go on to discuss the possible environmental factors associated with this type of abnormal growth / malignancy and that tumours can occur in the unpolluted environment of our ancient human ancestors.

 

1. Monge J, Kricun M, Radovčić J, Radovčić D, Mann A, Frayer DW. Fibrous Dysplasia in a 120,000+ Year Old Neandertal from Krapina, Croatia. PLoS ONE 2013 Jun;8(6):e64539. Available from: http://dx.doi.org/10.1371/journal.pone.0064539

2. Riddle ND, Bui MM. Fibrous dysplasia. Arch. Pathol. Lab. Med. 2013 Jan;137(1):134–138. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23276185

Pathology: Idiopathic granulomatous mastitis – a case report of breast abscess

11 Jan, 12 | by Emma

Here a biopsy of a non-resolving infective breast lesion reveals an entirely different pathology requiring a completely different treatment strategy. The importance of biopsy of non-resolving lesions is reiterated and the pathology and management discussed in detail.

Seema Biswas
Editor-in-Chief

Idiopathic granulomatous mastitis: a case report of breast abscess

Pathology: Primary bladder amyloidosis

2 Nov, 11 | by Emma

An 89 year old lady presents with painless haematuria and is found to have an extremely unusual lesion of the bladder. The pathology is discussed in detail and microscopy reveals stunning images…

Seema Biswas
Editor-in-Chief

Primary bladder amyloidosis

Pathology: Symptomatic malignant melanoma presenting as multiple gastrointestinal polyps

27 Oct, 11 | by Emma

A 66 year old gentleman who presents with nausea and intermittent diarrhoea is found to be anaemic. Gastroscopy and colonoscopy show multiple polyps but these polyps are a manifestation of an unusual pathology discussed here in some detail.

Seema Biswas
Editor-in-Chief

Symptomatic malignant melanoma presenting as multiple gastrointestinal polyps

Pathology: Spontaneous adrenal haemorrhage in pregnancy

20 Oct, 11 | by Emma

Here, the authors describe the case of a 20 year old lady 38 weeks into her pregnancy who experiences sudden onset chest and abdominal pain and presents with hypovolaemic shock. She undergoes emergency caesarean section but the cause of shock is not the most obvious pathology…

Seema Biswas
Editor-in-Chief

Spontaneous adrenal haemorrhage in pregnancy

Pathology: Topical treatment of contact dermatitis by pine processionary caterpillar

12 Oct, 11 | by Emma

Here a 65 year old gentleman who presents with pruritis of both forearms is found to have an unusual allergy. The pathology and mechanism of reaction is described in detail.

Seema Biswas
Editor-in-Chief

Topical treatment of contact dermatitis by pine processionary caterpillar

Pathology: Unusual pulmonary metastatic pattern in a case of pancreatic cancer

28 Sep, 11 | by Emma

Amongst the most educational case reports that we receive are the papers that discuss the pathology of patients in detail. The images are stunning and explanation of macro and micropathology a huge insight into disease processes. Here is the first in a selection…

A 70 year old gentleman presents with a productive cough which fails to resolve after repeated courses of antibiotics. The authors describe the series of investigations that ensue until the unusual cause of his symptoms is revealed…

Seema Biswas
Editor-in-Chief

Unusual pulmonary metastatic pattern in a case of pancreatic cancer

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