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Archive for October, 2012

Microbiology: Diphtheroids as a cause of endocarditis in a haemodialysis patient

31 Oct, 12 | by Emma

Dipheroids are usually regarded as skin or mucous membrane commensals. In this case from Jamaica the authors describe the role of the bacteria in fatal infective endocarditis.

Diphtheroids as a cause of endocarditis in a haemodialysis patient

Seema Biswas
Editor-in-Chief

TB: Systemic sarcoidosis with caseating granuloma

18 Oct, 12 | by Emma

In this case from Iran the authors tease out a diagnosis of TB from systemic sarcoidosis in a 58 year old woman.

Seema Biswas
Editor-in-Chief

Systemic sarcoidosis with caseating granuloma

TB: Crohn’s disease or TB – the perennial question and diagnostic pitfalls

11 Oct, 12 | by Emma

Here the authors describe a case of a non-healing perianal abscess in a patient from Saudi Arabia which finally responds to TB treatment…

Seema Biswas
Editor-in-Chief

Crohn’s disease or TB – the perennial question and diagnostic pitfalls

Crimean-Congo Viral Haemorrhagic Fever (CCVHF)

5 Oct, 12 | by Dr Dean Jenkins

A case of Crimean-Congo Viral Haemorrhagic Fever (CCVHF) has been diagnosed for the first time in the UK. The 38-year-old man had visited Afghanistan and fell ill a few days after he returned to Glasgow on a flight from Dubai. He has now been admitted to a specialist unit in the Royal Free Hospital in London.

http://www.bbc.co.uk/news/uk-scotland-glasgow-west-19846300

The clinical features show common dramatic progress characterized by hemorrhage, myalgia, and fever. Besides the direct infection of endothelium, indirect damage by viral or virus mediated host-derived soluble factors that cause endothelial activations and dysfunction occur. In diagnosis, enzyme linked immunoassay and real-time reverse transcription-polymerase chain reaction are used. Early diagnosis is critical for the patient and potential nosocomial infections. Supportive therapy is the essential part of the case management. Ribavirin was suggested as an effective drug in recent studies, and it was found to be beneficial. [1]

CCVHF is an Advisory Committee on Dangerous Pathogens Hazard Group 4 pathogen. Updated guidance on management of these viral haemorrhagic fevers was updated by the Department of Health in July this year. It includes advice on the transfer of confirmed cases to one of the UK’s high security infectious disease units.

1. Ergonul O. Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. Curr Opin Virol 2012 Apr;2(2):215–220. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22482717

TB: Coincident intra-abdominal presentation of lymphoma and tuberculosis after long-term iatrogenic immunosuppression

3 Oct, 12 | by Emma

A patient on long term therapy for Crohn’s disease presents acutely with bowel obstruction. Laparotomy and bowel resection is performed. Histopathological examination reveals a sinister cause…

Seema Biswas
Editor-in-Chief

Coincident intra-abdominal presentation of lymphoma and tuberculosis after long-term iatrogenic immunosuppression

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