Adverse effects of antidepressants in younger adults

  SSRIs might have higher rates of fracture than tricyclic antidepressants but lower mortality and adverse reactions. Carl Heneghan Antidepressants are commonly prescribed. Yet, in those under 65, there is scant evidence on the risks associated with their use. A recent publication in BMC  looked at these risks in a cohort of 20 to 64-year […]

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Do I need the drugs, doc? Heart failure drugs with preserved ejection fraction.

Evidence suggests heart failure patients with preserved ejection fraction could benefit from beta-blocker treatment, guidelines do not. Jack O’Sullivan   There is a well-established list of medications that work in heart failure with a reduced ejection fraction. However, it is unclear if these drugs are clinically effective in patients with heart failure with a preserved […]

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Crystalloids or saline?

  Use of resuscitation fluids has largely been based on physiological principles rather than evidence. Carl Heneghan The debate over when to use crystalloids versus saline in unwell adults shows there has been considerable uncertainty about what to do in practice. Use of resuscitation fluids has largely been based on physiological principles rather than evidence. […]

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Should asthma patients increase their steroid inhalers during an attack?

  EBM Practice Spotlight highlights new evidence that challenges current clinical practice Kamal Mahtani Asthma is a long-term condition affecting more than 300 million people (adults and children) worldwide. In the UK, it affects about 1 in every 10 people. When asthma management is effective, patients should be able to continue their normal activities of […]

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Why I am confused about lung cancer screening

  Should findings from a single trial inform decision making about lung cancer screening? Carl Heneghan, Editor in Chief   A recent cost-effective analysis of low-dose computed tomography for lung cancer screening targeted in those at highest risk of lung cancer suggests only modest benefits. The conclusion is based on a cost-effectiveness analysis of risk-targeted screening […]

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Prostate cancer now kills more people than breast cancer: cause for alarm?

  ‘As epidemiologists, we are not alarmed by the apparent ‘increase’ in deaths from prostate cancer,’ here’s why Jason Oke For the first time in the UK, the number of deaths from prostate cancer has exceeded the numbers of deaths from breast cancer. According to figures from the UK’s Office for National Statistics (ONS), more […]

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Evidence Watch: uncertainties with the evidence for influenza vaccination

  This week’s Evidence Watch highlights serious uncertainties with the current evidence-base for influenza vaccination Carl Heneghan, Editor in Chief  A systematic review of vaccines in the elderly [1] highlights the difference vaccination makes in a single season (lowers risk of influenza from 6% to 2.4%); but adds caution, in that we have very little […]

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