Will we ever learn? Probably not, because we are too confident: Heart failure drug doesn’t prevent heart failure, and sepsis drug doesn’t decrease mortality from sepsis.

 They all sound good at first. A decade later they don’t sound so good. Human recombinant activated protein C (HR APC; drotrecogin alfa; Xigris) addresses the pathophysiology of sepsis. It is low in sepsis and associated with death. Replacing it should work. So a randomized trial was done in 2001 (http://bit.ly/vQ0f5B) showing that it decreased […]

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