Do children and adults really differ?

@giordanopg recently tweeted a link about a paper in pre-publication from The Journal Of Pediatrics. It’s an analysis of a bunch of Cochrane reviews that had both child and adult RCTs included in a meta-analysis and asked the question “Do children and adults really differ?” Their technique was to compare the key outcomes by comparing […]

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FAST appraisals

I’m fairly sure you’ll remember the RAMbo method of reviewing the validity of single randomised controlled trials. And so I think that many readers will have been having sleepless afternoons, struggling through the lengths of a ‘User’s Guide’ checklist for systematic reviews thinking “Which action hero can rescue me from this mire?”. Or perhaps not. […]

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Risk vs. prognostic factors

The separation of ‘risk’ factors and ‘prognostic’ factors at first seems the sort of obsessive fine detail that gives epidemiologists and statisticians a bad name. Sadly, the difference is actually worth understanding for any clinician that’s going to try to cut through an observational study and understand what it might be truthfully telling us. (This […]

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