It’s how mixed up? Meta analysis models step one.

Well, I have to start with an apology. In one of these columns, I foolishly claimed that the difference between a Peto OR fixed effect meta-analysis and a DerSimonian-Laird random effects meta-analysis was pointlessly academic. It’s not. Now, this might start getting all statistical, but there is a clear and important difference. Meta-analysis comes in […]

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Diagnostic tests: as easy as I, II, III

Diagnostic testing keeps coming back to bite Archi, and that’s not just because of a probability-based failure about a small relative and a missed diagnosis of congenital heart disease. No, the problem with diagnostic tests and their use and abuse remains difficult because the methods of research, the quality of research and the consequence of […]

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“It ain’t what you say but the way that you say it”

Known and sung about from 1939 onwards, and beloved of puppy-trainers and parents of toddlers, it’s clear that how we say something is often more important than what we say. And we now know that this is true for how we write down clinical recommendations and indicate the weight of evidence behind them. (When I […]

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