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Endocrinology

Height screening programs

2 Apr, 08 | by Ian Wacogne

In a systematic review of the literature regarding height screening programs, there is incomplete data on their usefulness, but may cost approximately £30,000 per QALY.   Here.

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Vitamin D and Type 1 Diabetes

28 Mar, 08 | by Ian Wacogne

A systematic review of the evidence for Vitamin D supplementation in infancy and the subsequent development of type 1 diabetes suggests that supplementation may have a protective effect which may be dose related. Here.

Bone densiometry

25 Feb, 08 | by Ian Wacogne

In an audit of 576 children who had had DEXA scanning, although those who had fractures had marginally lower values, the predictive ability was poor.  Here.

Prader-Willi and scoliosis

9 Feb, 08 | by Ian Wacogne

In a series of 96 Dutch children with Prader-Willi, 37.5% had scoliosis, which can be related to age and body composition.  Here. 

Growth Hormone

21 Jan, 08 | by Ian Wacogne

Perspective: Petrou and McIntosh look at the methods of improving concordance with growth hormone therapy. Here.

Growth Hormone

21 Jan, 08 | by Ian Wacogne

In a study using a technique called conjoint analysis, which looks at consumer choices, a series of families were able to make choices about the device required to deliver growth hormone.  Here.

Traumatic Brain Injury

6 Nov, 07 | by Ian Wacogne

Of 117 survivors of severe traumatic brain injury admitted to an Australian PICU, 54 underwent screening or testing for pituitary dysfunction.  Of these, 9 had pituitary dysfunction, 4 with multiple hormonal deficiencies.   Here.

Klinefelter Syndrome

15 Oct, 07 | by Ian Wacogne

In a series of 24 boys with Klinefelter syndrome who were measured with DEXA had unfavourable muscle to fat ratio, which may be a precursor of the later life poor metabolic profile.  Here.

Obesity

8 Oct, 07 | by Ian Wacogne

DXA analysis of body fat in 1251 children suggests that gender and ethnicity have an impact which is not reflected by BMI analysis. Here.

Growth monitoring

8 Oct, 07 | by Ian Wacogne

After reviewing the literature this group present a set of criteria, with flow diagram, for referral of children for further assessment of their growth which detects 87.5% of children with Turner’s syndrome, and 76.5% of children with other disorders, with a false positive rate of 2%. Here.

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