In 102 patients with heart failure, use of a diuretic called torasemide was effective and had little or no effect on plasma electrolytes.  Here.

Do other people share my concerns about papers which talk about efficacy and safety in the same study?  One of the things about safety with respect to medicines is that it requires orders of magnitude larger studies to be able to make confident statements about it.  Here we’ve got 100 children who have had this loop diuretic, and none of them have had any major problems.  But when we talk about safety, in addition to the freqent minor problem, we’re also looking for the rare devestating problem aren’t we?  What if this medication had a devestating side effect in 1 in 500 patients?  I guess this is why in the UK we maintain the yellow card system.  Do you think we should let these authors have the statement they’ve put in the conclusion of their abstract?